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An examination was made of high dose non-treated immunoglobulin (NTIG) therapy at
an early stage of the West syndrome (WS). Six patients with cryptogenic WS who suffered
attacks ranging from 15 days to 6 months (mean 70 days) and 5 patients with symptomatic
WS who suffered attacks ranging from 14 days to 4 months (mean 32 days), were administered
NTIG 6–10 times intravenously at 100–200 mg/kg of body weight at intervals of 2 or
3 weeks. All patients with cryptogenic WS showed complete remission in accordance
with normalized electroencephalogram (EEG) without following anticonvulsants medication.
Of the 5 patients with symptomatic WS one patient showed cessation of clinical seizures
in agreement with EEG improvement and 2 other patients revealed transient cessation
of clinical seizures with recurrence. In cases of complete remission, the energy percentage
of the power spectrum for each frequency band displayed a tendency toward gradual
decrease of 8 wave band in correspondence with the increase of 6 wave band percentage
after NTIG therapy, suggesting that high dose NTIG may be useful for early treatment
of cryptogenic WS and for inhibiting brain deterioration owing to epileptic encephalopathy.
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References
- A prospective study of infantile spasms: clinical and therapeutic correlations.Epilepsia. 1983; 24: 135-158
- Traitment des Encephalopathies epileptiques de l'enfant par les gammaglobulines.Rev EEG Neurophysiol. 1977; 7: 443-447
- Effect des gammaglobulines sur des epilepsies rebelles.Ann Med Interne. 1979; 130: 307-312
- High dose gammaglobulin for intractable childhood epilepsy.Lancet. 1983; 8342: 162-163
- Early treatment of intractable childhood epilepsy with intravenous immunoglobulin.Nihon Univ J Med (Tokyo). 1984; 26: 229-242
- Intravenous gammaglobulin for post-encephalitic epilepsy.Lancet. 1984; 8412: 1154-1155
- Comparative study on non-treated and pepsintreated immunoglobulin therapy for idiopathic Lennox syndrome.Brain Dev (Tokyo). 1984; 6: 422-423
- Binding of normal human IgG for myelin sheaths, glia and neurons.Immunology. 1975; 28: 171-185
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© 1987 Published by Elsevier Inc.
