Research Article| Volume 9, ISSUE 4, P399-405, 1987

Cerebral lesions in early prematurity: EEG prognostic value in the neonatal period

      This paper is only available as a PDF. To read, Please Download here.
      The new radiological technics show the incidence of intraventricular hemorrhage (IVH), intraparenchymal hemorrhage (IPH), or of porencephaly (PL), in the neonatal period. Discrepancies between the initial extent of lesions and the outcome have been observed. We tried to appreciate the EEG value in infants having had such lesions during the first month of life. We studied serial EEG s and neuroradiological exams in 34 babies: with IVH (group I, 17 cases), with IPH and/'or PL (group II, 17 cases). Their gestational age (GA) was between 27 and 34 weeks; they all had a neurological follow-up between one and five years. Infants with favourable outcome (76% in gr. I, 47% in gr. II) had normal or slightly abnormal EEGs, whatever the extent of lesions. Nine babies had very abnormal EEGs (numerous positive rolandic spikes (PRSs) and/or EEG background without physiological rhythms); one developed moderate sequelae, the other 8 major sequelae (2 with infantile spasms). In gr. II, babies with major sequelae had a higher GA than babies with good outcome. The PRSs were more often observed with periventricular lesions than with IVH only and in babies with higher GA; they lasted up to 12 weeks on serial EEGs in one case with porencephaly (major sequelae with infantile spasms); they appeared before scan abnormality in another case which developed later porencephaly (major sequelae). Thus, EEGs give valuable information on brain function and help to forecast outcome in premature babies.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Williamson WD
        • Desmond MM
        • Wilson GS
        • Andrew L
        • Garcia-Prats JA
        Early neurodevelopmental outcome of low birth weight infants surviving neonatal intraventricular hemorrhage.
        JPerinatMed. 1982; 10: 34-40
        • Krishnamoorthy KS
        • Shannon DC
        • de Long GR
        • Todres ID
        • Davies KR
        Neurologic sequelae in the survivors of neonatal intraventricular hemorrhage.
        Pediatrics. 1979; 64: 233-237
        • Stewart AL
        • Thorburn RJ
        • Hope PL
        • Goldsmith N
        • Lipscomb AP
        • Reynolds EOR
        Ultrasound appearance of the brain in very preterm infant and neurodevelopment at 18 months of age.
        Arch Dis Child. 1983; 58: 598-604
        • Fawer CL
        • Levene MJ
        • Dubowitz LMS
        Intraventricular haemorrhage in a preterm neonate: discordance between clinical course and ultrasound scan.
        Neuropediatrics. 1983; 14: 242-244
        • Radvanyi-Bouvet MF
        • Fazzi E
        • de Bethma O
        Evoluzione electro-clinica nelle emorragie intraventriculari e nelle leucomalacia del prematuro.
        in: Rossolini Primo anno di vita: organizazione e sviluppo della patologia neuropsichica. Top studio, Urbino1984: 502
        • Tharp B
        • Cukier F
        • Monod N
        Valeur prognostique de l'EEG du premature.
        Rev EEG Neurophysiol. 1977; 7: 386-391
      1. Radvanyi MF, Morel-Kahn F. L’EEG chez le prématuré pathologique. In: Cavazutti GB, ed. J problemi neurologici del neonato di basso peso. Atti del primo convegno di neurologia neonatale, 1979:69–72.

        • Cukier F
        • André M
        • Monod N
        • Dreyfus-Brisac C
        Apport de l’EEG au diagnostic des hémorragies intraventriculaires des prématurés.
        Rev EEG Neurophysiol. 1972; 2: 318-322
        • Murat I
        Intérêt discriminatif des pointes positives rolandiques.
        in: Contribution au diagnostic des hémorragies intraventriculaires. Université René Descartes, Paris1978 (offset, 52 pp. Thèse med.)
        • Blume WT
        • Dreyfus-Brisac C
        Positive rolandic sharp waves in neonatal EEG: types and significance.
        Electroencephalogr Clin Neurophysiol. 1982; 53: 277-282
        • Dreyfus-Brisac C
        Neonatal electroencephalography.
        in: Scarpelli Cosmi Review in perinatal medicine. Vol 3. Raven Press, New York1979: 397-472
        • Radvanyi-Bouvet MF
        • Vallecalle MH
        • Morel-Kahn F
        • Relier JP
        • Dreyfus-Brisac C
        Seizures and electrical discharges in premature infants.
        Neuropediatrics. 1985; 16: 143-148
        • Watanabe K
        • Hakamada S
        • Kuroyanagi M
        • Yamazaki T
        • Takeuchi T
        Electroencephalographic study of intraventricular hemorrhage in the preterm newborn.
        Neuropediatrics. 1983; 14: 225-230
        • Clancy RC
        • Tharp BR
        Positive rolandic sharp waves in the electroencephalograms of premature neonates with intraventricular hemorrhage.
        Electroencephalogr Clin Neurophysiol. 1984; 57: 395-404
        • Ropert JC
        • Navelet Y
        • D’Allest AM
        • et al.
        Etude de la valeur diagnostique de l’EEG au cours des hémorragies péri et intra-ventriculaires du nouveauné.
        Arch Fr Pediatr. 1980; 37: 381-384