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Neonatal EEG, cerebral evoked potentials, CT scan findings and their evolution were
investigated in 42 neonates who eventually developed the West syndrome. In infants
with perinatal hypoxia, the EEG displayed most often marked or maximal depression
in the first week of life. The highly abnormal initial EEG improved progressively
with time. The most frequent findings in early infancy was discontinuous tracing and
persistent alternating tracing at 1–2 months, and absent sigma rhythms at 3–4 months.
The VEP, AEP and CT scan also showed findings suggesting severe degree of brain damage.
In infants with meningitis, the initial EEG was less depressed but the EEG abnormality
persisted or worsened. In infants with prenatal causes the neonatal EEG was variable,
ranging from a normal background EEG to specific abnormalities. The evolution of paroxysmal
abnormalities was similar in all groups. There were no epileptiform discharges in
early months. The appearance of hypsarrhythmia was preceded by focal and then multifocal
spike or sharp wave discharges.
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© 1987 Published by Elsevier Inc.
