Research Article| Volume 9, ISSUE 1, P16-20, 1987

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The standardization of hyperventilation on EEG recording in childhood I. The quantity of hyperventilation activation

  • Tohru Konishi
    Correspondence address: Dr. Tohru Konishi, Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama 930-01, Japan.
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama
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      In thirty-seven children free of neurological symptoms, we attempted the standardization of hyperventilation on EEG. We also attempted to determine the quantity of hyperventilation activation necessary to produce equivalent degrees of EEG slowing at different ages. The respiratory rate (RR), total expiratory volume/min (VE), O2 consumption volumeJ min (VO2), expiratory CO2 volume/min (VO2), tcpO2 and tcpCO2 were monitored before, during and after hyperventilationn. The optimal conditions for adequate activation were found to be: a respiratory rate of 30/min, a 3-fold elevation of VE and a duration of 4 minutes. With this activation, the degree of EEG slowing was found to be nearly inversely proportional to the age (in the age range of 6 years to 17 years old). Therefore, this activation may be adequate and useful for evaluating the EEG development in childhood. As to the relationship between the appearance of EEG slowing and changes in respiratory factors, the pCO2 decrease and the cerebral blood flow decrease, which may be evoked by the pCO2 decrease, are the most fundamental factors that produce EEG slowing during hyperventilation. The difference in the response on hyperventilation between children and adults may be due to age-related CNS sensitivity to CO2 and/or cerebral vascular CO2 responsiveness.

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        • Gibbs FA
        • Gibbs EL
        • Lennox WG
        Electroencephalographic response to overventilation and its relation to age.
        J Pedktr. 1943; 23: 497-505
        • Davis H
        • Wallace WM
        Factors affecting changes produced in the EEG by standardized hyperventilation.
        Arch Neurol Psychiatry. 1942; 47: 606-625
        • Meyer JS
        • Gotoh F
        Metabolic and electroencephalographic effects of hyperventilation.
        Arch Neurol. 1960; 5: 539-552
        • Meyer JS
        • Waltz AG
        Arterial oxygen saturation and alveolar carbon dioxide during electroencephalography.
        Arch Neurol. 1960; 2: 631-643
        • Gotoh F
        • Meyer JS
        • Takagi Y
        Cerebral effects of hyperventilation in man.
        Arch Neurol. 1965; 12: 410-423
        • Cain SM
        An attempt to demonstrate cerebral anoxia during hyperventilation of anesthetized dogs.
        Am J Physiol. 1963; 204: 323-326
        • Wasserman AJ
        • Patterson JL
        The cerebral vascular response to reduction in arterial carbon dioxide tension.
        J Clin Invest. 1961; 40: 1297-1303
        • Hauge A
        • Thoresen M
        • Walloe L
        Changes in cerebral blood flow during hyperventilation and CO2-breathing measured transcutaneously in humans by a bidirectional, pulsed, ultrasound doppler blood velocitymeter.
        Acta Physiol Scand. 1980; 110: 167-173
        • Hansen NB
        • Brubakk AM
        • Bratlid D
        • Oh W
        • Stonestreet BS
        Brain blood flow response to CO2 in newborn pigets.
        Pediatr Res. 1983; 17: 316
        • Rosenkrantz TS
        • Oh W
        Aminophylline reduces cerebral blood flow velocity in low-birth-weight infants.
        Am J Dis Child. 1987; 138: 489-491
        • Holmberg G
        The electroencephalogram during hypoxia and hyperventilation.
        Electroencephalogr Clin Neurophysiol. 1953; 5: 371-376
        • Morrice JKW
        Slow wave production in the EEG, with reference to hyperpnoea, carbon dioxide and autonomic balance.
        Electroencephalogr Clin Neurophysiol. 1956; 8: 49-72
        • Silverman D
        A comparison of hyperventilation and apnoea activation of the EEG.
        Electroencephalogr Clin Neurophysiol. 1956; 8: 41-48
        • Swanson A
        • Stavney LS
        • Plum F
        Effects of blood pH and carbon dioxide on cerebral electrical activity.
        Neurology. 1958; 8: 787-792
        • Preswick G
        • Reivich M
        • Hill ID
        The effects of combined hyperventilation and hypoxia in normal subjects.
        Electroencephalogr Clin Neurophysiol. 1965; 18: 56-64
        • Brickford RG
        A standard ventilometer for use in routine electroencephalography.
        Electroencephalogr Clin Neurophysiol. 1949; 1: 522
        • Sasaki M
        • Suzuki M
        • Karasawa A
        Build-up phenomenon in normal adults. Re-evaluation on the standardization of hyperventilation (in Japanese).
        Rinshonoha (Osaka). 1981; 8: 517-523
        • Sasaki M
        • Sato J
        • Mori A
        • Suzuki M
        • Magara A
        Effects of hyperventilation on EEG (in Japanese).
        Noha To Kindenzu (Tokyo). 1982; 10: 154-161
        • Sakai Y
        A standardization of hyperventilation — Device of “HV monitor” (in Japanese).
        Rinshonoha (Osaka). 1982; 24: 492-496
        • Rogers MC
        • Nugent SK
        • Traystman RJ
        Control of cerebral circulation in the neonate and infant.
        Crit Care Med. 1980; 8: 570-574