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In thirty-seven children free of neurological symptoms, we attempted the standardization
of hyperventilation on EEG. We also attempted to determine the quantity of hyperventilation
activation necessary to produce equivalent degrees of EEG slowing at different ages.
The respiratory rate (RR), total expiratory volume/min (VE), O2 consumption volumeJ min (VO2), expiratory CO2 volume/min (VO2), tcpO2 and tcpCO2 were monitored before, during and after hyperventilationn. The optimal conditions
for adequate activation were found to be: a respiratory rate of 30/min, a 3-fold elevation
of VE and a duration of 4 minutes. With this activation, the degree of EEG slowing
was found to be nearly inversely proportional to the age (in the age range of 6 years
to 17 years old). Therefore, this activation may be adequate and useful for evaluating
the EEG development in childhood. As to the relationship between the appearance of
EEG slowing and changes in respiratory factors, the pCO2 decrease and the cerebral blood flow decrease, which may be evoked by the pCO2 decrease, are the most fundamental factors that produce EEG slowing during hyperventilation.
The difference in the response on hyperventilation between children and adults may
be due to age-related CNS sensitivity to CO2 and/or cerebral vascular CO2 responsiveness.
Key Words
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References
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Article info
Publication history
Accepted:
August 25,
1986
Received:
February 17,
1986
Identification
Copyright
© 1987 Published by Elsevier Inc.
