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Administration of ACTH at two different doses (0.05 and 0.5 μg/g/day) to suckling
rats resulted in the suppression of both the body and brain weight gains and the developmental
increase in brain CNPase activity, and the suppression of the brain CNPase activity
persisted for 3 weeks (up to the end of the experiment) after the cessation of ACTH
administration in the suckling period, while the suppression of the body and brain
weight gains was noticed only during the administration period.
The authors emphasized the possibility that long-term therapy with massive doses of
ACTH for infantile spasms may be hazardous to the developing brain in many ways.
Key words
Abbreviations used:
ACTH (adrenocorticotropin), CNS (central nervous system), CNPase (2′,3′-cyclic nucleotide 3′-phosphohydrolase), CT (computerized tomography), GH (growth hormone), NADPH (B-nicotinamide adenine dinucleotide phosphate, reduced form), vs (versus)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
February 18,
1986
Received:
August 27,
1985
Footnotes
*This work was partly supported by a research grant from the Ministry of Health and Welfare, Japan (No 83-05-01), and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan (No 58770704).
Identification
Copyright
© 1986 Published by Elsevier Inc.
