Advertisement

Suppression of 2′, 3′- Cyclic nucleotide 3′-Phosphohydrolase activity in suckling rat brain by ACTH

      This paper is only available as a PDF. To read, Please Download here.
      Administration of ACTH at two different doses (0.05 and 0.5 μg/g/day) to suckling rats resulted in the suppression of both the body and brain weight gains and the developmental increase in brain CNPase activity, and the suppression of the brain CNPase activity persisted for 3 weeks (up to the end of the experiment) after the cessation of ACTH administration in the suckling period, while the suppression of the body and brain weight gains was noticed only during the administration period.
      The authors emphasized the possibility that long-term therapy with massive doses of ACTH for infantile spasms may be hazardous to the developing brain in many ways.

      Key words

      Abbreviations used:

      ACTH (adrenocorticotropin), CNS (central nervous system), CNPase (2′,3′-cyclic nucleotide 3′-phosphohydrolase), CT (computerized tomography), GH (growth hormone), NADPH (B-nicotinamide adenine dinucleotide phosphate, reduced form), vs (versus)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Sorel L
        • Dusaucy-Bauloye A
        A propos de 21 cas d’hypsarhythmie de Gibbs. Son traitement spectaculaire par l’ACTH.
        Acta Neurol Psychiatr Belg. 1958; 58: 130-141
        • Howard E
        • Benjamins JA
        DNA, ganglioside and sulfatide in brains of rats given corticosterone in infancy, with an estimate of cell loss during development.
        Brain Res. 1975; 92: 73-87
        • Martin SM
        • Morberg GP
        Effects of Cortisol administration on development of the thyroid and adrenal axes in rats.
        Life Sci. 1982; 31: 2577-2581
        • Noguchi T
        • Sugisaki T
        • Watanabe M
        • Kohsaka S
        • Tsukada Y
        Effects of bovine growth hormone on the retarded cerebral development induced by neonatal hydrocortisone intoxication.
        J Neurochem. 1982; 38: 246-256
        • Blodgett FM
        • Burgin L
        • Iezzoni D
        • Gribetz D
        • Talbot NB
        Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children.
        N Engl J Med. 1956; 254: 636-641
        • Palo J
        • Savolainen H
        The effect of high doses of synthetic ACTH on rat brain.
        Brain Res. 1974; 70: 313-320
        • Strand FL
        • Kung TT
        ACTH accelerates recovery of neuromuscular function following crushing of peripheral nerve.
        Peptides. 1980; 1: 135-138
        • Bijlsma WA
        • van Asselt E
        • Veldman H
        • Jennekens FGI
        • Schotman P
        • Gispen WH
        Ultrastructural study of effect of ACTH4–10 on nerve regeneration; axons become larger in number and smaller in diameter.
        Acta Neuropathol (Bed). 1983; 62: 24-30
        • Sogin D
        2′,3′-cyclic NADP as a substrate for 2′,3′-cyclic nucleotide 3′-phosphohydrolase.
        J Neurochem. 1976; 27: 1333-1337
        • Lowry OH
        • Rosebrough NJ
        • Farr AL
        • Randall RJ
        Protein measurement with the Folin phenol reagent.
        J Biol Chem. 1951; 193: 265-275
        • Drummond GI
        • Iyer NT
        • Keith J
        Hydrolysis of ribonucleoside 2′, 3′-cyclic phosphates by diesterase from brian.
        J Biol Chem. 1962; 237: 3535-3559
        • Kurihara T
        • Tsukada Y
        The regional and subcellular distribution of 2′, 3′-cyclic nucleotide 3′-phosphohydrolase in the central nervous system.
        J Neuroch em. 1967; 14: 1167-1174
        • Waehneldt TV
        Ontogenetic study of a myelin -derived fraction with 2′,3′-cyclic nucleotide 3′-phosphohydrolase activity higher than that of myelin.
        Biochem J. 1975; 151: 435-437
        • Lagenstein I
        • Willig RP
        • Kuehne D
        Cranial computed tomography (CCT) findings in children with ACTH and dexamethasone: first results.
        Neuropediatrics. 1979; 10: 370-384
        • Satoh J
        • Takeshige H
        • Hara H
        • Fukuyama Y
        Brain shrinkage and subdural effusion associated with ACTH administration.
        Brain Dev (Tokyo). 1982; 4: 13-20
        • Howard E
        Effects of cortisone and food restriction on growth and on DNA, RNA and cholesterol contents of the brain and liver in infant mice.
        J Neurochem. 1965; 12: 181-191
        • Cotterrell M
        • Balazs R
        • Johnson AL
        Effects of corticosteroids on the biochemical maturation of rat brain: postnatal cell formation.
        J Neurochem. 1972; 19: 2151-2167
        • Frantz AG
        • Rabkin MT
        Human growth hormone: clinical measurement, response to hypoglycemia and suppression by corticosteroids.
        N EnglJMed. 1964; 271: 1375-1381
        • Hartog M
        • Gaafar MA
        • Fraser R
        Effect of corticosteroids on serum growth hormone.
        Lancet. 1964; 1: 376-378
        • Pecile A
        • Müller E
        Suppressive action of corticosteroids on the secretion of growth hormone.
        J Endocrinol. 1966; 36: 401-408
        • Sawano S
        • Arimura A
        • Schally AV
        • Redding TW
        • Schapiro S
        Neonatal corticoid administration: effects upon adult pituitary growth hormone and hypothalamic growth hormone-releasing hormone activity.
        Acta Endocrinol. 1969; 61: 57-67
        • Izumi T
        • Fukuyama Y
        Influence of ACTH on serum hormone content and its anticonvulsant action towards infantile spasms.
        Life Sci. 1984; 34: 1023-1028
        • Izumi T
        • Imaizumi C
        • Ashida E
        • Ochiai T
        • Wang PJ
        • Fukuyama Y
        Suppressive action of ACTH on growth hormone secretion in patients with infantile spasms.
        Brain Dev. 1985; 7: 636-639
        • Noguchi T
        • Sugisaki T
        • Tsukada Y
        Postnatal action of growth and thyroid hormones on the retarded cerebral myelinogenesis of snell dwarf mice (dw).
        J Neurochem. 1982; 38: 257-263
        • Noguchi T
        • Sugisaki T
        • Takamatsu K
        • Tsukada Y
        Factors contributing to the poor myelination in the brain of the snell dwarf mouse.
        J Neurochem. 1983; 39: 1693-1699
        • Serlieve LL
        • Bouchon R
        • Koehl C
        • Neskovic NM
        Cerebroside and sulfatide biosynthesis in the brain of snell dwarf mouse: effects of thyroxine and growth hormone in the early postnatal period.
        J Neurochem. 1983; 40: 1058-1062
        • Noguchi T
        • Sugisaki T
        Hypomyelination in the cerebrum of the congenitally hypothyroid mouse (hyt).
        J Neurochem. 1984; 42: 891-893