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By means of the Doppler ultrasound method, the cerebral blood flow (CBF) was assessed
in 21 children with epilepsy undergoing treatment with adrenocorticotrophic hormone
(ACTH). The maximum reduction in the internal carotid velocity, as an index of CBF
during therapy, was about 35 percent compared with the values before therapy. Furthermore,
sequential computed tomography (CT) examinations of the same subjects were performed
to evaluate the change in the area of the intracranial brain parenchyma during therapy.
The maximum reduction in the parenchymal area during therapy was about 10 percent.
This corresponds to a 20 percent reduction in CBF according to Poiseuille's law, however,
the remaining reduction in CBF demonstrated by velocity measurement cannot be explained
only by that mechanical vascular factor.
From these findings, it is concluded that in order to elucidate the mechanism of the
CBF reduction, physiological factors such as changes in metabolism during therapy
should also be evaluated in addition to the mechanical and physical causes.
Key words
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Article info
Publication history
Accepted:
June 30,
1986
Received:
May 8,
1986
Identification
Copyright
© 1986 Published by Elsevier Inc.