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By means of the Doppler ultrasound method, the cerebral blood flow (CBF) was assessed
in 21 children with epilepsy undergoing treatment with adrenocorticotrophic hormone
(ACTH). The maximum reduction in the internal carotid velocity, as an index of CBF
during therapy, was about 35 percent compared with the values before therapy. Furthermore,
sequential computed tomography (CT) examinations of the same subjects were performed
to evaluate the change in the area of the intracranial brain parenchyma during therapy.
The maximum reduction in the parenchymal area during therapy was about 10 percent.
This corresponds to a 20 percent reduction in CBF according to Poiseuille's law, however,
the remaining reduction in CBF demonstrated by velocity measurement cannot be explained
only by that mechanical vascular factor.
From these findings, it is concluded that in order to elucidate the mechanism of the
CBF reduction, physiological factors such as changes in metabolism during therapy
should also be evaluated in addition to the mechanical and physical causes.
Key words
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References
- Reversible cerebral atrophy in infantile spasms caused by corticotrophin.Lancet. 1979; 2: 37-38
- Reversible cerebral atrophy and corticotrophin.Lancet. 1979; 2: 207
- Cranial computed tomography (CT) findings in children treated with ACTH and dexamethasone: first results.Neuropädiatrie. 1979; 10: 37-84
- Two cases of infantile spasms with cerebral atrophy after ACTH therapy (in Japanese).No To Hattatsu (Tokyo). 1979; 11: 353-359
- Apparent cerebral atrophy in patients on treatment with steroids.Dev Med Child Neurol. 1980; 22: 502-506
- Sequential CT studies of 24 children with infantile spasms on ACTH therapy.Dev Med Child Neurol. 1983; 25: 475-480
- Experimental effect of steroids and steroid withdrawal on cerebrospinal fluid absorption.J Neurosurg. 1975; 42: 690-695
- The effect of ACTH on suckling rats.Brain Dev (Tokyo). 1984; 6: 545-550
- Effect of ACTH on water content of rat brain (in Japanese).No To Hattatsu. 1985; 17: 325-329
- The effect of ACTH on cerebral blood flow in children with intractable epilepsy.Brain Dev (Tokyo). 1985; 7: 53-55
- The effects of increased intracranial pressure on cerebral circulatory functions in man.J Clin Invest. 1948; 27: 493-499
- The evaluation of cerebral blood flow in children with epilepsy treated with ACTH (in Japanese).Nihon-shonika-gakkai-zasshi (Tokyo). 1985; 89: 1920-1925
- Internal carotid blood flow velocity in children with cerebral palsy by Doppler ultrasound method.Brain Dev (Tokyo). 1982; 4: 27-33
- Internal carotid velocity measurements in children with cerebrovascular disease.Brain Dev (Tokyo). 1983; 5: 363-370
- Doppler carotid velocity measurements as an index of total cerebral blood flow.in: Bes A Gillers G Cerebral circulation and neurotransmitters. Elsevier North-Holland Inc, New York1980: 93-99
- Prediction of hemispheric blood flow from carotid velocity measurement. A study with the Doppler and 133Xe inhalation techniques.Stroke. 1980; 11: 399-402
- Cerebral blood flow in children with intractable epilepsy.Brain Dev (Tokyo). 1983; 5: 36-40
- Microvascular blood flow: evidence indicating a cubic dependence on arteriolar diameter.Am J Physiol. 1983; 245: H1031-H1038
- Cerebral blood flow and oxygen consumption in man.Physiol Rev. 1959; 39: 183-238
- Cerebral 2-deoxyglucose accumulation in mice following chronic treatment with an ACTH4–9 analog, ORG 2766.Brain Res Bull. 1984; 12: 369-371
- Alterations in local cerebral glucose utilization during chronic treatment with an ACTH4–9 analog.Eur J Pharmacol. 1982; 78: 151-158
- The influence of corticosteroids and theophylline on cerebral function.Chest. 1982; 82: 181-185
- Depressed mood and other psychiatric manifestations of Cushing's syndrome: relationship to hormone levels.Psychosom Med. 1981; 43: 3-18
Article info
Publication history
Accepted:
June 30,
1986
Received:
May 8,
1986
Identification
Copyright
© 1986 Published by Elsevier Inc.
