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The present study on ACTH-administered suckling rats was undertaken to monitor the
late behavioral sequelae due to the effects of this drug. The locomotor activity of
rats treated with ACTH in the suckling period increased significantly as to the gross
size of movements when compared with control rats. The increase in locomotor activity
was correlated with the suppression of CNPase activity. These results show that administration
of ACTH during the suckling period has suppressive effects on the development of the
brain and behavior, and that these effects persist for a longer period after termination
of the administration of ACTH than the direct effect of the peptide on endocrine functions.
Key words
Abbreviations used:
ACTH (adrenocorticotrophic hormone), CNS (central nervous system), CNPase (2′,3′-cyclic nucleotide 3′-phosphohydrolase), NADP (β-nicotinamide adenine dinucleotide phosphate), vs (versus)To read this article in full you will need to make a payment
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Article Info
Publication History
Accepted:
April 15,
1986
Received:
March 10,
1986
Footnotes
§This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan (No. 60770757).
Identification
Copyright
© 1986 Published by Elsevier Inc.
