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Administration of ACTH to suckling rats results in hyperkinetic behavior

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      The present study on ACTH-administered suckling rats was undertaken to monitor the late behavioral sequelae due to the effects of this drug. The locomotor activity of rats treated with ACTH in the suckling period increased significantly as to the gross size of movements when compared with control rats. The increase in locomotor activity was correlated with the suppression of CNPase activity. These results show that administration of ACTH during the suckling period has suppressive effects on the development of the brain and behavior, and that these effects persist for a longer period after termination of the administration of ACTH than the direct effect of the peptide on endocrine functions.

      Key words

      Abbreviations used:

      ACTH (adrenocorticotrophic hormone), CNS (central nervous system), CNPase (2′,3′-cyclic nucleotide 3′-phosphohydrolase), NADP (β-nicotinamide adenine dinucleotide phosphate), vs (versus)
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      References

        • Sorel L
        • Dusaucy-Bauloye A
        A propos de 21 cas d’hypsarhythmie de Gibbs. Son traitement spectaculaire par l’ACTH.
        Acta Neurol Psychiatr Belg. 1958; 58: 130-141
        • Lagenstein I
        • Willig RP
        • Kühne D
        Cranial computed tomography (CCT) findings in children with ACTH and dexamethasone: first results.
        Neuropädiatrie. 1979; 10: 370-384
        • Lyen LR
        • Holland IM
        • Lyen YC
        Reversible cerebral atrophy in infantile spasms caused by cortico-trophin.
        Lancet. 1979; II: 37-38
        • Deonna T
        • Voumard C
        Reversible cerebral atrophy and corticotrophin.
        Lancet. 1979; II: 207
        • Maekawa K
        • Ohta H
        • Tamai I
        KüTransient brain shrinkage in infantile spasms after ACTH treatment. A report of two cases.
        Neuropädiatrie. 1980; 11: 80-84
        • Walravens P
        • Chase HP
        Influence of thyroid on formation of myelin lipids.
        J Neurochem. 1969; 16: 1477-1484
        • Wysocki SJ
        • Segal W
        Influence of thyroid hormones on enzyme activities of myelinating rat central-nervous tissues.
        Eur J Biochem. 1972; 28: 183-189
        • Neskovic NM
        • Sarlieve LL
        • Mandel P
        Alteration of the glycolipid biosynthesis in the hypopituitary dwarf mouse.
        Brain Res. 1980; 184: 523-525
        • Noguchi T
        • Sugisaki T
        • Watanabe M
        • Kohsaka S
        • Tsukada Y
        Effects of bovine growth hormone on the retarded cerebral development induced by neonatal hydrocortisone intoxication.
        J Neurochem. 1982; 38: 246-256
        • Noguchi T
        • Sugisaki T
        • Tsukada Y
        Postnatal action of growth and thyroid hormones on the retarded cerebral myelinogenesis of snell dwarf mice (dw).
        J Neurochem. 1982; 38: 257-263
        • Sarlieve LL
        • Bouchon R
        • Koehl C
        • Neskovic NM
        Cerebroside and sulfatide biosynthesis in the brain of snell dwarf mouse: effects of thyroxine and growth hormone in the early postnatal period.
        J Neurochem. 1983; 40: 1058-1062
        • Izumi T
        • Fukuyama Y
        Influence of ACTH on serum hormone content and its anticonvulsant action towards infantile spasms.
        Life Sci. 1984; 34: 1023-1028
        • Izumi T
        • Imaizumi C
        • Ashida E
        • Ochiai T
        • Wang PJ
        • Fukuyama Y
        Suppressive action of ACTH on growth hormone secretion in patients with infantile spasms.
        Brain Dev (Tokyo). 1985; 7: 636-639
        • Izumi T
        • Shishikura K
        • Fukuyama Y
        Suppression of 2′,3′-cyclic nucleotide 3-phosphohydrolase activity in suckling rat brain by ACTH.
        Brain Dev (Tokyo). 1986; 8: 500-504
        • Sogin D
        2′,3′-Cyclic NADP as a substrate for 2′, 3′-cyclic nucleotide 3-phosphohydrolase.
        J Neurochem. 1976; 27: 1333-1337
        • Kato N
        • Sundmark VC
        • Van Middlesworth L
        • Havlicek V
        • Friesen HG
        Immunoreactive somatostatin and β-endorphin content in the brain of mature rats after neonatal exposure to propylthiouracil.
        Endocrinology. 1982; 110: 1851-1855
        • Lowry OH
        • Rosebrough NJ
        • Farr AL
        • Randall RJ
        Protein measurement with the Folin phenol reagent.
        J Biol Chem. 1951; 193: 265-275
        • Evans HS
        • Simpson ME
        • Li CH
        Inhibiting effect of adrenocorticotrophic hormone on growth of male rats.
        Endocrinology. 1943; 33: 237-238
        • Blodgett FM
        • Burgin L
        • Iezzoni D
        • Gribetz D
        • Talbot NB
        Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children.
        N Engl J Med. 1956; 254: 636-641
        • Howard E
        Effects of cortisone and food restriction on growth and DNA, RNA and cholesterol contents of the brain and liver in infant mice.
        J Neurochem. 1965; 12: 181-191
        • Cotterrell M
        • Balázs R
        • Johnson AL
        Effects of corticosteroids on the biochemical maturation of rat brain: postnatal cell formation.
        J Neurochem. 1972; 19: 2151-2167
        • Martin SM
        • Morberg GP
        Effects of Cortisol administration on development of the thyroid and adrenal axes in rats.
        Life Sci. 1982; 31: 2577-2581
        • Kurihara T
        • Tsukada Y
        The regional and subcellular distribution of 2′, 3′-cyclic nucleotide 3′-phosphohydrolase in the central nervous system.
        J Neurochem. 1967; 14: 167-174
        • Wehneldt TV
        Ontogenetic study of a myelinderived fraction with 2′,3′-cylic nucleotide 3′-phosphohydrolase activity higher than that of myelin.
        Biochem J. 1975; 151: 435-437
        • Tsukada Y
        • Nomura M
        • Nagai K
        • et al.
        Neurochemical correlates of learning ability.
        in: Delgado JMR DeFendis FV Behavioral neurochemistry. Spectrum, New York1977: 63-84