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Developmental changes of neurons containing neuron-specific enolase (NSE) in human
brain were studied in various areas of the central nervous system by immunohistochemistry
with the peroxidase-antiperoxidase (PAP) method.
In the brain stem, Purkinje cells, dentate nucleus, globus pallidus and thalamus,
the number of NSE-positive neurons increased from an early period in gestation. However,
in the pontine nucleus and putamen, it gradually increased along with decreasing cellularity
later in gestation and in the infantile period. In the cerebral cortex, NSE-positive
neurons developed as late as in the putamen and their cellularity increased earlier
in the 5th layer than in the 3rd layer.
Developmental changes of NSE-positive neurons parallel phylogenesis. The appearance
of NSE-positive neurons can be a marker of neuronal maturation.
Key words
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Article info
Publication history
Accepted:
December 5,
1984
Received:
September 20,
1984
Identification
Copyright
© 1985 Published by Elsevier Inc.
