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To elucidate the changes of free amino acid patterns in brains of El mice induced
by several anticonvulsants, the free amino acid levels in brains were measured by
an amino acid autoanalyzer 24 hours after intraperitoneal injection of PB, PHT or
vitamin B6 or subcutaneous injection of ACTH.
Compared to the preconvulsion group, the total free amino acid level increased in
the ACTH group clearly. In the PB group, the levels of threonine, glutamine, lysine,
histidine and homocarnosine increased and that of ornithine decreased; in the PHT
group, an increase of glutamine and histidine and a decrease of β-alanine and ornithine
were observed; in the ACTH group, an increase of aspartic acid, threonine, serine,
glutamic acid, glutamine, alanine and GABA and a decrease of cystathionine and ornithine
were also observed; and in the vitamin B6 group, an increase of taurine and a decrease
of cystathionine were recognized.
These facts suggest that the sedative activity of these drugs except ACTH might be
partially explained by the increase of inhibitory amino acids in the brain, such as
glutamine, homocarnosine and taurine, and that of ACTH by the dehydration of the brain,
resulting in concentration of many free amino acids.
Key words
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Article Info
Publication History
Accepted:
January 31,
1984
Received:
September 22,
1983
Identification
Copyright
© 1984 Published by Elsevier Inc.
