Abstract
Background
As there have been no comprehensive reports of human metapneumovirus-associated encephalopathy
(hMPVE), this study examined the clinical features of hMPVE in children in Japan.
Method
A nationwide survey of children with hMPVE was conducted using a structured research
form. An initial survey asked pediatricians about children with hMPVE treated between
2014 and 2018. A second survey obtained patient information from hospitals that responded
to the initial survey and those identified as having treated cases from a literature
search. We collected demographic data, symptoms of hMPV infection, neurological symptoms,
laboratory data, treatment, and outcomes. Outcomes were determined using the Pediatric
Cerebral Performance Category Score.
Result
Clinical information was available for 16 children. Their median age was 37 months.
Six had preexisting neurological disorders. The interval between the onsets of infection
and hMPVE was 4 days. Outcomes were good in 11 patients and poor in 5. There were
no significant differences in demographic data, neurological symptoms, or laboratory
data between the patients with good and poor outcomes. The encephalopathy subtypes
were acute encephalopathy with biphasic seizures and late reduced diffusion in 3,
clinically mild encephalitis/encephalopathy with a reversible splenial lesion in 3,
hemorrhagic shock and encephalopathy syndrome in 2, and others in 8.
Conclusion
The outcomes of children with hMPVE were not very different from those of acute encephalopathy
due to other viruses. We found no factors associated with poor outcomes.
Keywords
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Article info
Publication history
Published online: January 24, 2023
Accepted:
January 3,
2023
Received in revised form:
December 13,
2022
Received:
August 22,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Published by Elsevier B.V. on behalf of The Japanese Society of Child Neurology. All rights reserved.
