Abstract
Background
Since 1990's, the cognitive profile of children with a neurofibromatosis type 1 (NF1)
has been refined by many different studies. Children with NF1 may exhibit a variety
of cognitive dysfunctions. Memory difficulties have been reported, but the results
are contradictory and, compared to other cognitive functions, memory has been less
evaluated.
Objective
The aim of this study was to investigate the memory profile in NF1 with a particular
population, children with NF1 without attention deficit hyperactivity disorder (ADHD).
Methods
Eighteen children with NF1 without ADHD and eighteen typically developing aged from
8 to 12.6 years were compared in terms of both their verbal and visual working memory,
anterograde memory, and procedural perceptual-motor memory. We also assessed semantic
and autobiographical memory.
Results
Our results indicate the existence of memory difficulties in children with NF1 without
ADHD in verbal working and anterograde memory but not in terms of the visual domain.
They also experienced difficulties recalling personal memories but these were improved
by cueing. However, semantic memory and procedural perceptual-motor memory was preserved.
Conclusions
These results highlight a difference between memory systems in children with NF1 without
ADHD and the importance to assess the different memory systems, the nature of information
and the processes in long-term memory in NF1 population. However, our results raise
questions about the possible links between these difficulties and the executive functions.
The specifics of memory profile in children with NF1 must be taken into consideration
in these children’s clinical follow-up, in order to understand their learning difficulties
and to make adaptations to their care.
Keywords
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Article info
Publication history
Published online: January 04, 2023
Accepted:
December 12,
2022
Received in revised form:
December 6,
2022
Received:
July 13,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Published by Elsevier B.V. on behalf of The Japanese Society of Child Neurology.
