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Tendency and risk factors of acute pancreatitis in children with severe motor and intellectual disabilities: A single-center study

Published:November 07, 2022DOI:https://doi.org/10.1016/j.braindev.2022.10.007

      Abstract

      Objective

      Acute pancreatitis (AP) is a life-threatening disease in children with severe motor and intellectual disabilities (SMID). This study aimed to determine the clinical characteristics and causes of AP in children with SMID.

      Methods

      We enrolled 29 children with AP admitted to our hospital. Patients were divided into children with SMID (AP with SMID group) and the remaining patients (AP without SMID group). All patients in the AP without SMID group had no pre-existing neurological disabilities. We obtained data on the clinical background of patients, severity of AP, treatments, and outcomes. We enrolled 34 children with SMID without a history of AP (SMID control group) to compare their clinical characteristics with the AP with SMID group. We statistically compared the data between the AP with SMID and AP without SMID groups and between the AP with SMID and SMID control groups.

      Result

      Compared to the AP without SMID group, the AP with SMID group showed significantly more severe pancreatitis (50% vs 12%) and recurrent pancreatitis (58% vs 18%). Moreover, compared with the SMID control group, the AP with SMID group showed significantly more frequent absence of voluntary movement (83% vs 26%), requirement of respiratory devices (75% vs 35%), panhypopituitarism (33% vs 6%), thermoregulatory dysfunction (58% vs 18%), and low serum albumin levels (3.6 vs 4.1 g/dL).

      Conclusion

      AP in children with SMID tended to be associated with severe and recurrent pancreatitis. Children with SMID who had a history of AP had more severe neurological impairment among children with SMID. Hypothalamic-pituitary system dysfunction caused by severe cerebral damage may contribute to the development of AP.

      Keywords

      Abbreviations:

      AP (acute pancreatitis), SMID (severe motor and intellectual disabilities), BSA (body surface area), BMI (body mass index), INSPPIRE (International study group of pediatric pancreatitis: in search for cure), TPN (total parenteral nutrition), TRH (Thyrotropin-releasing hormone)
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