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Regarding the impact of maternal dyslipidemia on infant neurodevelopment

Published:September 27, 2022DOI:https://doi.org/10.1016/j.braindev.2022.09.003
      We commend Motoki and colleagues for their notable contribution to the growing body of literature through an examination of the possible role of maternal dyslipidemia in pregnancy complications and infant neurodevelopmental disorders. Using scores from the Ages and Stages Questionnaire, third edition (ASQ-3), they concluded that hypercholesterolemia may have a deleterious effect on infant neurodevelopment and age-appropriate acquisition at 12 months [
      • Motoki N.
      • Inaba Y.
      • Shibazaki T.
      • et al.
      Impact of maternal dyslipidemia on infant neurodevelopment: The Japan Environment and Children's Study.
      ]. As discussed in the manuscript, limitations of this study included a high participant attrition rate, self-reporting of ASQ-3 data by participants, and variance between Japanese and historic American infantile score data. As Motoki et al. indicate, it is still unclear whether neurodevelopmental evaluations at 12 months are clinically pertinent for subsequent diagnosis, warranting a longitudinal study extending beyond the analyzed cohort.
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