Abstract
Objective
The diagnosis of attention deficit/hyperactivity disorder (AD/HD) in Japan is mainly
based on information obtained from caregivers. There is therefore a need to establish
an objectivity index that can be easily used in clinical practice. The purpose of
the study was to create a predictive model for the diagnosis of AD/HD using the MOGRAZ,
a visual continuous performance test developed in Japan.
Methods
We collected data from an AD/HD group and a non-AD/HD group. The AD/HD group included
75 children with predominantly inattentive type AD/HD and 48 with combined type AD/HD
who were aged 6 to 12 years and diagnosed at our department. The non-AD/HD group included
153 Japanese children aged 6 to 11 years enrolled in regular classes at a public elementary
school. In both groups, multiple logistic regression analysis was performed using
the results of MOGRAZ, age, and sex as parameters, and algorithms for a predictive
diagnostic model of AD/HD were created.
Results
The area under the receiver operating characteristic curve (ROC-AUC) between the predominantly
inattentive type AD/HD subgroup and non-AD/HD group was 0.884 (95% confidence interval:
0.837–0.932), and the ROC-AUC between the combined type AD/HD subgroup and non-AD/HD
group was 0.914 (95% CI: 0.869–0.959).
Conclusion
The prediction model using the MOGRAZ score allowed us to create an objectivity index
to determine the diagnosis of AD/HD that can be easily used in clinical practice.
We plan additional verification of this prediction model with additional participants.
Keywords
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References
- Diagnostic and Statistical Manual of Mental Disorders.Fifth Edition. APA, Washington, DC2013
- Attention deficit hyperactivity disorder.Lancet. 2016; 387: 1240-1250
- Sustained and transient attention in the continuous performance task.J Clin Exp Neuropsychol. 2006; 28: 859-883
- Assessing attention: comparison of response-inhibition and traditional continuous performance tests.J Clin Exp Neuropsychol. 2001; 23: 331-350
- Continuous performance test performance in a normative epidemiological sample.J Abnorm Child Psychol. 2003; 31: 555-562
- Relations between Continuous Performance Test performance measures and ADHD behaviors.J Abnorm Child Psychol. 2003; 31: 543-554
- Is the Continuous Performance Task a valuable research tool for use with children with Attention-Deficit-Hyperactivity Disorder?.J Child Psychol Psychiatry. 1993; 34: 1217-1239
- The d' measure of signal detectability during viligance-like situations.Can J Psychol. 1963; 17: 302-325
- A continuous performance test of brain damage.J Consult Psychol. 1956; 20: 343-350
- The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families.Psychiatry Res. 1988; 26: 223-238
- The test of variables of attention (TOVA) is useful in the diagnosis of Japanese male children with attention deficit hyperactivity disorder.Brain Dev. 2000; 22: 378-382
- Evaluating vigilance deficits in ADHD: a meta-analysis of CPT performance.J Abnorm Psychol. 2012; 121: 360-371
- Usefullness of continuous performance test (CPT) for children with Attention deficit/hyperactivity disorder (ADHD) (in Japanese).Clin Electroencephalogr. 2003; 45: 384-388
- A study of visual sustained attention in normal children and children with attention deficit/hyperactivity disordewr by visual continuous performance task “MOGRAZU” (in Japanese).J Integrat Center Clin Educat Pract. 2010; 9: 91-100
- Development and abnormality of the function of attention using continuous performance test (MOGRAZ) (in Japanese).Clin Electroencephalogr. 2007; 49: 1-5
- Continuous Performance Test (CPT) using Personal Computer in Children with Attention Deficit/Hyperactivity Disorders (ADHD) (in Japanese).Japan J Clin Neurophysiol. 2006; 34: 152-159
- Continuous performance task in ADHD: Is reaction time variability a key measure?.Neuropsychiatr Dis Treat. 2018; 14: 781-786
- Gender differences among children with ADHD on continuous performance tests: a meta-analytic review.J Atten Disord. 2012; 16: 190-198
- Gender Differences in Objective and Subjective Measures of ADHD Among Clinic-Referred Children.Front Hum Neurosci. 2019; 13: 441
- Sustained attention and response inhibition in young children at risk for Attention Deficit/Hyperactivity Disorder.J Child Psychol Psychiatry. 2005; 46: 1219-1229
- ADHD History of the Concept: the Case of the Continuous Performance Test.Curr Develop Disord Rep. 2015; 2: 10-22
- Nonpatient CPT performance varying target frequency and interstimulus interval on five response measures.Arch Clin Neuropsychol. 2004; 19: 1017-1025
- Reaction time variability in ADHD: a review.Neurotherapeutics. 2012; 9: 500-508
- A meta-analytic study of event rate effects on Go/No-Go performance in attention-deficit/hyperactivity disorder.Biol Psychiatry. 2012; 72: 990-996
- Beyond the dual pathway model: evidence for the dissociation of timing, inhibitory, and delay-related impairments in attention-deficit/hyperactivity disorder.J Am Acad Child Adolesc Psychiatry. 2010; 49: 345-355
- Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation.Front Hum Neurosci. 2018; 12: 100
- Comorbidity prevalence and treatment outcome in children and adolescents with ADHD.Eur Child Adolesc Psychiatry. 2017; 26: 1443-1457
- The Co-Occurrence of Autism Spectrum Disorder in Children With ADHD.J Atten Disord. 2020; 24: 94-103
- Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study.Atten Defic Hyperact Disord. 2015; 7: 27-38
- Comorbidity of ADHD and reading disability among clinic-referred children.J Abnorm Child Psychol. 1990; 18: 29-45
- Attention deficit disorder and specific reading disability: separate but often overlapping disorders.J Learn Disabil. 1991; 24: 96-103
- The assessment of comorbid disorders in ADHD children and adolescents.Adv Med Sci. 2007; 52: 215-217
- Executive function deficits and neural discordance in children with Autism Spectrum Disorders.Clin Neurophysiol. 2009; 120: 1107-1115
- Autism and attention deficit hyperactivity disorder: assessing attention and response control with the integrated visual and auditory continuous performance test.Child Neuropsychol. 2006; 12: 335-348
- Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages.Brain Cogn. 2006; 61: 25-39
- Children with Attention Deficit/Hyperactivity Disorder and Pervasive Developmental Disorder: Attention and Response Inhibition on the Kiddie Continuous Performance Test (in Japanese).No To Hattatsu. 2011; 43: 367-371
- Attention profiles in autistic children with and without comorbid hyperactivity and attention problems.Acta Neuropsychiatr. 2008; 20: 207-215
- Attention Deficits in Children With Combined Autism and ADHD: A CPT Study.J Atten Disord. 2016; 20: 599-609
- Behavioural and neurophysiological correlates of dyslexia in the continuous performance task.Clin Neurophysiol. 2007; 118: 845-855
- Performance patterns in Conners' CPT among children with attention deficit hyperactivity disorder and dyslexia.Arq Neuropsiquiatr. 2012; 70: 91-96
Article Info
Publication History
Published online: July 22, 2022
Accepted:
July 8,
2022
Received in revised form:
July 8,
2022
Received:
July 2,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 The Japanese Society of Child Neurology Published by Elsevier B.V. All rights reserved.
