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Original article| Volume 44, ISSUE 9, P605-611, October 2022

Verification of the ability of the new MRI classification system to predict neurodevelopmental outcome in very low-birth-weight infants

Published:July 04, 2022DOI:https://doi.org/10.1016/j.braindev.2022.06.005
Verification of the ability of the new MRI classification system to predict neurodevelopmental outcome in very low-birth-weight infants
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      Abstract

      Background

      Very low-birth-weight infants (VLBWI) are at high risk for adverse neurodevelopmental outcomes. A new, feasible and practical classification system for white matter injury has been reported by Martinez-Biarge et al. Therefore, we investigated the relationship between white matter injury and neurodevelopmental outcomes using this system.

      Materials and methods

      We enrolled a consecutive series of VLBWI birth weights <1500 g between 2012 and 2015. Two radiologists evaluated the brain MRI obtained in the VLBWI at term-equivalent age. MRI findings were classified into six Grades (Grade 0, Ia, Ib, II, III, IV). The frequency of abnormalities in each Grade was examined. The neurodevelopmental outcome of the VLBWI was assessed at two years or older, and we investigated the presence of cerebral palsy (CP) and intellectual disability (ID), and other serious outcomes. We also calculated the simple kappa value before the raters were matched.

      Results

      Among 167 VLBWI, 131 met the eligibility criteria. 114 was Grade 0 (87%), 11 was Grade I (8.4%), 3 was Grade II (2.3%), 1 was Grade III (0.8%), and 2 was Grade IV (1.5%). The frequency of any abnormalities of intelligence in Grade 0 was 24%. The frequency of CP in Grade I was 18%. All Grade III and Grade IV cases had mild CP and an ID. The simple kappa value was 0.95.

      Conclusion

      The prognostic value of the MRI scoring tool was limited. However, all Grade III and Grade IV cases had mild CP and ID. The results demonstrated an excellent inter-rater correlation.

      Keywords

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      Article info

      Publication history

      Published online: July 04, 2022
      Accepted: June 19, 2022
      Received in revised form: June 14, 2022
      Received: January 28, 2022

      Identification

      DOI: https://doi.org/10.1016/j.braindev.2022.06.005

      Copyright

      © 2022 The Japanese Society of Child Neurology Published by Elsevier B.V. All rights reserved.

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