Abstract
Introduction
The aim of this study is to investigate a possible association between vitamin D deficiency
and diabetic peripheral neuropathy in pediatric patients with type 1 diabetes mellitus.
Materials-methods
Twenty-nine patients with type 1 diabetes mellitus and 19 healthy controls were included
to the study. All individuals were evaluated for diabetic peripheral neuropathy with
nerve conduction studies. Complete blood cell count, biochemical investigations, serum
vitamin D levels, hemoglobin A1c levels were recorded.
Results
No statistically significant differences between the diabetes and control groups in
terms of gender, age, body weight, height, body mass index, systolic and diastolic
blood pressures, laboratory investigations, serum vitamin D levels and nerve conduction
studies was found. Patients with diabetes were grouped as patients with normal serum
vitamin D levels and patients with vitamin D deficiency. Sensory nerve action potential
of sural nerve and motor peroneal nerve velocity were statistically significantly
lower in diabetic patients with vitamin D deficiency compared to diabetic patients
with normal vitamin D levels (p 0.009 and 0.005 respectively).
Conclusion
Our results suggested that hypovitaminosis D might lead to development of neuropathic
changes particularly on the lower limb nerves even in the early stages of the disease.
It should be kept in mind that patients with hypovitaminosis D should be elaborately
examined and closely followed up for the development of diabetic neuropathic changes,
even if glucose control is achieved.
Keywords
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Article info
Publication history
Published online: January 15, 2022
Accepted:
January 3,
2022
Received in revised form:
December 13,
2021
Received:
August 30,
2021
Identification
Copyright
© 2022 Published by Elsevier B.V. on behalf of The Japanese Society of Child Neurology.
