Abstract
Objective
To quantitatively evaluate regional cerebral blood flow (rCBF) and regional developmental
changes during childhood using 123I-N-isopropyl-iodoamphetamine single-photon emission computed tomography (SPECT) and
autoradiography.
Methods
We retrospectively analyzed quantitative values of rCBF in 75 children (29 girls)
aged between 16 days and 178 months (median: 12 months), whose brain images, including
magnetic resonance imaging and SPECT data, were normal under visual inspection at
Saitama Children’s Medical Center between 2005 and 2015. The subjects had normal psychomotor
development, no focal neurological abnormalities, and neither respiratory nor cardiac
disease at the time of examination. Regions of interest were placed automatically
using a three-dimensional stereotactic template.
Results
rCBF was lowest in neonates, who had greater rCBF in the lenticular nucleus, thalamus,
and cerebellum than the cerebral cortices. rCBF increased rapidly during the first
year of life, reaching approximately twice the adult levels at 8 years, and then fell
to approximately adult levels in the late teenage years. Cerebral cortex rCBF sequentially
increased in the posterior, central, parietal, temporal, and callosomarginal regions
during infancy and childhood.
Conclusions
rCBF changed dramatically throughout childhood and ranged from lower than adult values
to approximately two times higher than adult values. It had different trajectories
in each region during brain development. Understanding this dynamic developmental
change is necessary for SPECT image evaluation in children.
Keywords
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Article info
Publication history
Published online: July 02, 2018
Accepted:
June 9,
2018
Received in revised form:
February 2,
2018
Received:
October 8,
2017
Identification
Copyright
© 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
