Association of developing childhood epilepsy subsequent to febrile seizure: A population-based cohort study

  • Author Footnotes
    1 These authors are contributed equally to this work.
    Lin-Mei Chiang
    Footnotes
    1 These authors are contributed equally to this work.
    Affiliations
    Department of Pediatric, Keelung Branch, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
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  • Author Footnotes
    1 These authors are contributed equally to this work.
    Go-Shine Huang
    Footnotes
    1 These authors are contributed equally to this work.
    Affiliations
    Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taiwan
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  • Chi-Chin Sun
    Affiliations
    Department of Ophthalmology, Keelung Branch, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Department of Chinese Medicine, Chang Gung University, Taoyuan, Taiwan
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  • Ying-Li Hsiao
    Affiliations
    Department of Medical Research and Development, Keelung Branch, Chang Gung Memorial Hospital, Taiwan
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  • Chung Kun Hui
    Affiliations
    Department of Anesthesiology, Keelung Branch, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
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  • Mei-Hua Hu
    Correspondence
    Corresponding author at: Division of Pediatric General Medicine, Chang Gung Memorial Hospital, LinKou Branch, College of Medicine, Chang Gung University, 12L, No.5, Fu-Shin Street, Kwei-shan 333, Taoyuan, Taiwan.
    Affiliations
    Division of Pediatric General Medicine, Chang Gung Memorial Hospital, LinKou Branch, College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
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  • Author Footnotes
    1 These authors are contributed equally to this work.

      Abstract

      Purpose

      Epilepsy is an important neurological condition that frequently associated with neurobehavioral disorders in childhood. Our aim was to identify the risk of developing epilepsy subsequent to febrile seizure and the association between epilepsy risk factors and neurobehavioral disorders.

      Subjects and methods

      This longitudinal population-based cohort data included 952 patients with a febrile seizure diagnosis and 3808 age- and sex-matched controls. Participants were recruited for the study from 1996 to 2011, and all patients were followed up for maximum 12.34 years.

      Results

      The association of epilepsy was significantly higher (18.76-fold) in individuals that experienced febrile seizure compared to controls. Further, of those individuals who experienced febrile seizure, the frequency of subsequent development of epilepsy was 2.15-fold greater in females, 4.846-fold greater in patients with recurrent febrile seizure, and 11.26-fold greater patients with comorbid autism.

      Conclusions

      Our study showed that being female, comorbid autism with febrile seizure and recurrent febrile seizure had an increased association with development of epilepsy. Increased recognition the association for epilepsy might be warranted in those febrile seizure children with certain characteristics.

      Keywords

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