Abstract
Introduction
A mutation at nucleotide position 3435 in exon 26 of the multidrug resistance 1 (MDR1)
gene is the most frequently studied polymorphism in relation to multidrug resistance.
However, there are conflicting data as to whether the CC or TT genotype of the 3435C>T
polymorphism is associated with drug resistance. Methods and results: We investigated the association between this polymorphism in drug-resistant childhood
epilepsy by comparison with drug-responsive patients. In total, 59 patients with drug-resistant
epilepsy, defined as having four or more seizures within a 12-month period while using
three or more AEDs, 60 children with drug-responsive epilepsy who had remained seizure-free
for 12 months on their current AED regimen and 76 healthy children were involved in this
study. Genotype frequencies in drug-resistant patients were as follows: 32.2% CC,
44.1% CT, 23.7% TT; in the drug-responsive group: 20.0% CC, 50.0% CT, 30.0% TT; in
the control group: 24.3% CC, 50.0% CT, 25.7% TT. Comparison of drug-resistant and
drug-responsive patients revealed no significant difference in genotype frequency.
The findings of the epilepsy patients were not significantly different from those
of the healthy control subjects. Conclusions: Our study does not support any significant association between the MDR1 polymorphism
and drug-resistant childhood epilepsy.
Keywords
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Article info
Publication history
Published online: March 06, 2013
Accepted:
January 30,
2013
Received in revised form:
September 10,
2012
Received:
June 13,
2012
Identification
Copyright
© 2013 The Japanese Society of Child Neurology. Published by Elsevier Inc. All rights reserved.
