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Neurobehavioral and hemodynamic evaluation of Stroop and reverse Stroop interference in children with attention-deficit/hyperactivity disorder

Published:February 15, 2013DOI:https://doi.org/10.1016/j.braindev.2013.01.005

      Abstract

      Failure of executive function (EF) is a core symptom of attention-deficit/hyperactivity disorder (ADHD). However, various results have been reported and sufficient evidence is lacking. In the present study, we evaluated the characteristics of children with ADHD using the Stroop task (ST) and reverse Stroop task (RST) that reflects the inhibition function of EF. We compared children with ADHD, typically developing children (TDC), and children with autism spectrum disorder (ASD), which is more difficult to discriminate from ADHD. A total of 10 children diagnosed with ADHD, 15 TDC, and 11 children diagnosed with ASD, all matched by age, sex, language ability, and intelligence quotient, participated in this study. While each subject performed computer-based ST and RST with a touch panel, changes in oxygenated hemoglobin (oxy-Hb) were measured in the prefrontal cortex (PFC) by near-infrared spectroscopy (NIRS) to correlate test performance with neural activity. Behavioral performance significantly differed among 3 groups during RST but not during ST. The ADHD group showed greater color interference than the TDC group. In addition, there was a negative correlation between right lateral PFC (LPFC) activity and the severity of attention deficit. Children with ADHD exhibit several problems associated with inhibition of color, and this symptom is affected by low activities of the right LPFC. In addition, it is suggested that low hemodynamic activities in this area are correlated with ADHD.

      Keywords

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      References

        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders.
        4th ed. American Psychiatric Association, Washington (DC)2000
        • Barkley R.A.
        • Grodzinsky G.
        • DuPaul G.J.
        Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report.
        J Abnorm Child Psychol. 1992; 20: 163-188
        • Martel M.
        • Nikolas M.
        • Nigg J.T.
        Executive function in adolescents with ADHD.
        J Am Acad Child Adolesc Psychiatry. 2007; 46: 1437-1444
        • Willcutt E.G.
        • Doyle A.E.
        • Nigg J.T.
        • Faraone S.V.
        • Pennington B.F.
        Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review.
        Biol Psychiatry. 2005; 57: 1336-1346
        • Pennington B.F.
        • Ozonoff S.
        Executive functions and developmental psychopathology.
        J Child Psychol Psychiatr Allied Disc. 1996; 37: 51-87
        • King J.A.
        • Colla M.
        • Brass M.
        • Heuser I.
        • von Cramon D.
        Inefficient cognitive control in adult ADHD: evidence from trial-by-trial Stroop test and cued task switching performance.
        Behav Brain Funct. 2007; 3: 42
        • Lansbergen M.M.
        • Kenemans J.L.
        • van Engeland H.
        Stroop interference and attention-deficit/hyperactivity disorder: a review and meta-analysis.
        Neuropsychology. 2007; 21: 251-262
        • Rapport L.J.
        • Hanks R.A.
        • Millis S.R.
        • Deshpande S.A.
        Executive functioning and predictors of falls in the rehabilitation setting.
        Arch Phys Med Rehabil. 1998; 79: 629-633
        • Reeve W.V.
        • Schandler S.L.
        Frontal lobe functioning in adolescents with attention deficit hyperactivity disorder.
        Adolescence. 2001; 36: 749-765
        • Negoro H.
        • Sawada M.
        • Iida J.
        • Ota T.
        • Tanaka S.
        • Kishimoto T.
        Prefrontal dysfunction in attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy.
        Child Psychiatry Hum Dev. 2010; 41: 193-203
        • Song Y.
        • Hakoda Y.
        An asymmetric Stroop/reverse-Stroop interference phenomenon in ADHD.
        J Atten Disord. 2011; 15: 499-505
        • Matsuda G.
        • Hiraki K.
        Sustained decrease in oxygenated hemoglobin during video games in the dorsal prefrontal cortex: a NIRS study of children.
        Neuroimage. 2006; 29: 706-711
        • Ehlis A.C.
        • Bähne C.G.
        • Jacob C.P.
        • Herrmann M.J.
        • Fallgatter A.J.
        Reduced lateral prefrontal activation in adult patients with attention-deficit/hyperactivity disorder (ADHD) during a working memory task: a functional near-infrared spectroscopy (fNIRS) study.
        J Psychiatr Res. 2008; 42: 1060-1067
        • Inoue Y.
        • Sakihara K.
        • Gunji A.
        • Ozawa H.
        • Kimiya S.
        • Shinoda H.
        • et al.
        Reduced prefrontal hemodynamic response in children with ADHD during the Go/NoGo task: a NIRS study.
        Neuroreport. 2012; 23: 55-60
        • Kita Y.
        • Gunji A.
        • Inoue Y.
        • Goto T.
        • Sakihara K.
        • Kaga M.
        • et al.
        Self-face recognition in children with autism spectrum disorders: a near-infrared spectroscopy study.
        Brain Dev. 2011; 33: 494-503
        • Sumitani S.
        • Tanaka T.
        • Tayoshi S.Y.
        • Ota K.
        • Kameoka N.
        • Ueno S.
        • et al.
        Activation of the prefrontal cortex during the Wisconsin card sorting test as measured by multichannel near-infrared spectroscopy.
        Neuropsychobiology. 2006; 53: 70-76
        • Hill E.L.
        Evaluating the theory of executive dysfunction in autism.
        Dev Rev. 2004; 24: 189-233
        • Boyd B.A.
        • McBee M.
        • Holtzclaw T.
        • Baranek G.T.
        • Bodfish J.W.
        Relationships among repetitive behaviors, sensory features, and executive functions in high functioning autism.
        Res Autism Spectr Disord. 2009; 3: 959-966
        • Happe F.
        • Ronald A.
        The ‘Fractionable Autism Triad’: a review of evidence from behavioural, genetic cognitive and neural research.
        Neuropsychol Rev. 2008; 18: 287-304
        • Raven J.
        Coloured progressive matrices: sets A, Ab, B.
        OPP Ltd., Oxford1976
        • Bussing R.
        • Fernandez M.
        • Harwood M.
        • Hou Wei
        • Garvan C.W.
        • Eyberg S.M.
        • et al.
        Parent and teacher SNAP-IV ratings of attention deficit hyperactivity disorder symptoms: psychometric properties and normative ratings from a school district sample.
        Assessment. 2008; 15: 317-328
        • Jensen P.
        • Arnold L.
        • Severe J.
        • Vitiello B.
        • Hoagwood K.
        • Grp M.C.
        National institute of mental health multimodal treatment study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder.
        Pediatrics. 2004; 113: 754-761
        • Shimada S.
        • Hiraki K.
        Infant’s brain responses to live and televised action.
        Neuroimage. 2006; 32: 930-939
        • Moriguchi Y.
        • Hiraki K.
        Neural origin of cognitive shifting in young children.
        Proc Natl Acad Sci USA. 2009; 106: 6017-6021
        • Tannock R.
        • Martinussen R.
        • Frijters J.
        Naming speed performance and stimulant effects indicate effortful, semantic processing deficits in attention-deficit/hyperactivity disorder.
        J Abnorm Child Psychol. 2000; 28: 237-252
        • Catale C.
        • Meulemans T.
        The real animal size test (RAST): a new measure of inhibitory control for young children.
        Eur J Psychol Assess. 2009; 25: 83-91
        • Benowitz L.I.
        • Bear D.M.
        • Rosenthal R.
        • Mesulam M.M.
        • Zaidel E.
        • Sperry R.W.
        Hemispheric specialization in nonverbal communication.
        Cortex. 1983; 19: 5-11
        • Blonder L.X.
        • Bowers D.
        • Heilman K.M.
        The role of the right hemisphere in emotional communication.
        Brain. 1991; 114: 1115-1127
        • Asahi S.
        • Okamoto Y.
        • Okada G.
        • Yamawaki S.
        • Yokota N.
        Negative correlation between right prefrontal activity during response inhibition and impulsiveness: a fMRI study.
        Eur Arch Psychiatry Clin Neurosci. 2004; 254: 245-251
        • Matsumoto K.
        • Tanaka K.
        Neuroscience. Conflict and cognitive control.
        Science. 2004; 303: 969-970
        • Sanefuji M.
        • Takada Y.
        • Kimura N.
        • Torisu H.
        • Kira R.
        • Ishizaki Y.
        • et al.
        Strategy in short-term memory for pictures in childhood: a near-infrared spectroscopy study.
        Neuroimage. 2011; 54: 2394-2400
        • Schroeter M.L.
        • Zysset S.
        • Wahl M.
        • von Cramon D.Y.
        Prefrontal activation due to Stroop interference increases during development – an event-related fNIRS study.
        Neuroimage. 2004; 23: 1317-1325
        • Tsujimoto S.
        • Yamamoto T.
        • Kawaguchi H.
        • Koizumi H.
        • Sawaguchi T.
        Prefrontal cortical activation associated with working memory in adults and preschool children: an event-related optical topography study.
        Cereb Cortex. 2004; 14: 703-712
        • Otsuka Y.
        • Nakato E.
        • Kanazawa S.
        • Yamaguchi M.K.
        • Watanabe S.
        • Kakigi R.
        Neural activation to upright and inverted faces in infants measured by near infrared spectroscopy.
        Neuroimage. 2007; 34: 399-406