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A servo system including a microwave generator was applied to raise a rats body temperature
at a preset rate. Using this system the effects of age and the temperature elevation
rate upon febrile seizures in rats were studied. The relationship between the brain
GABA content and hyperthermia was also studied. From the results of the present study,
the seizure occurrence rate was found to be highest at the age of 20 days, brain damage
was speculated to be severe after hyperthermia-induced seizures with a slow temperature
rise, and the regional GABA concentration in subcortical structures was found to increase
during hyperthermia. These data indicate that a servo system with a microwave generator
is useful for experimental febrile convulsions, and that GABA neurotransmission in
subcortical structures might contribute to feed-back regulation against seizures during
hyperthermia.
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References
- Factors influencing the relationship of convulsions and hyperthermia.J Pediatr. 1939; 14: 190-201
- Studies in febrile seizures. I. Height of body temperature as a measure of the febrile-seizure threshold.Pediatrics. 1959; 23: 76-85
- Hyperthermia-induced seisures in the rat pup: a mode for febrile convulsions in children.Science. 1981; 213: 1034-1036
- Experimental febrile convulsions: long-term effects of hyperthermia-induced convulsions in developing rats.Epilepsia. 1982; 23: 173-190
- Microwavehyperthermia model of febrile convulsions.Bioelectromagnetics. 1983; 4: 341-355
- Physiologic and biochemical changes resulting from exposure to an ultrahigh frequency field.Arch Pathol. 1931; 11: 728-743
- Experimental febrile convulsions in the developing rat: effects on the cholinergic system.Epilepsia. 1984; 25: 250-258
- GABA in cerebrospinal fluid of children with febrile convulsions.Epilepsia. 1981; 22: 697-702
- γ-Aminobutyric acid in CSF of children with febrile seizures.Arch Neurol. 1985; 42: 474-475
- Regional studies of catecholamines in the ratbrain-1.J Neurochem. 1966; 13: 655-659
- Role of γ-aminobutyric acid (GABA) in the extrapyramidal motor system. Regional distribution of GABA in rabbit, rat, guinea pig and baboon CNS.Exp Brain Res. 1971; 13: 514-518
- Seizure pattern in young animals. Significance of brain carbonic anhydrase. II.Proc Soc Exp Biol Med. 1958; 97: 606-611
- Ultrastructure of the developing cerebral cortex in the rat.in: Sterman MB Brain development and behavior. Academic Press, New York1971: 91-107
- Development of cortical activity in the rat.Exp Neurol. 1967; 17: 425-437
- Febrile convulsions: a reappraisal.Electroencephalogr Gin Neurophysiol. 1973; : 32
- Effect of alteration in body temperature on properties of convulsive seizures in rats.Am J Physiol. 1948; 154: 207-210
Article info
Publication history
Accepted:
October 21,
1989
Received:
July 20,
1989
Identification
Copyright
© 1990 Published by Elsevier Inc.
