Research Article| Volume 13, ISSUE 1, P47-51, January 1991

Clinical and neuropathological findings in severe athetoid cerebral palsy: A comparative study of globo-Luysian and thalamo-putaminal groups

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      We divided cases of severe athetoid cerebral palsy originating perinatally into two groups neuropathologically, the “globo-Luysian group” (GL) and the “thalamo-putaminal group” (TP). The major abnormal sites in GL were the pallidum and subthalamic nucleus, and in TP the thalamus and putamen. The lesions in TP were more widespread and frequently accompanied by fibrillary gliosis in the central gray matter of the midbrain, and subthalamic nuclei were dominantly devastated. Concerning the etiology, GL and TP were related to perinatal severe jaundice and neonatal asphyxia, respectively. The patients in TP showed lower mental ability and suffered from more intractable convulsions than those in GL. In GL, rigidospasticity was frequently demonstrated with fluctuation of athetoid movements, while in TP various abnormalities of muscle tone were observed, with rather restricted athetosis.

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        • Spiegel EA
        • Baird HW
        Athetotic syndrome.
        in: Vinken PJ Bruyn GW Handbook of clinical neurology, Vol 6. Diseases of the basal ganglia. North-Holland Publ Co., Amsterdam1968: 440-475
        • Morimatsu Y
        • Matsuyama H
        • Shinohara T
        • Tamagawa K
        • Oda M
        Problems related to cerebral palsy [5] — pathological study of cerebral palsy (in Japanese).
        Sogo Rihabiriteishon (Tokyo). 1979; 7: 877-888
        • Narabayashi H
        • Nagahata M
        • Nagao T
        • Shimazu H
        A new classification of cerebral palsy based on neurophysiologic considerations.
        Confin Neurol. 1965; 25: 378-392
        • Morimatsu Y
        • Shinohara T
        • Koya G
        • Handa T
        • Murofushi K
        • Shiraki H
        Pathological studies of the severe physically and mentally handicapped with special reference to pathological changes of the thalamus (in Japanese).
        Shinkei Kenkyu no Shinpo (Tokyo). 1973; 17: 93-105
        • Morimatus Y
        • Satoh J
        • Mizutani T
        • et al.
        Thalamic lesions in the developmental disabilities—focusing on the cases of brain injury sustained in the perinatal period.
        in: Abstracts of the 10th International Congress of Neuropathology, Stockholm1986: 285
        • Morimatsu Y
        • Tamagawa K
        • Satoh J
        • Mizutani T
        • Shinohara T
        • Sakamoto K
        A neuropathological study of severe mental retardation.
        Congenital Anomalies (Nagoya). 1983; 23: 445-459
        • Satoh J
        • Mizutani T
        • Morimatsu Y
        Neuropathology of the brainstem in age-dependent epileptic encephalopathy—especially of cases with infantile spasms.
        Brain Dev (Tokyo). 1986; 8: 443-449
        • Malamud N
        • Itabashi HH
        • Castor J
        • Messinger HB
        An etiologic and diagnostic study of cerebral palsy—a preliminary report.
        J Pediatr. 1964; 65: 270-293
        • Andersen P
        • Andersson SA
        • Lomo T
        Some factors involved in the thalamic control of spontaneous barbiturate spindles.
        J Neurophysiol. 1967; 192: 257-281
        • Gibbs FA
        • Gibbs EL
        Atlas of electroencephalography, Vol 3. Neurological and psychiatric disorders. Addison-Wesley Publishing Company, Massachusetts·Palo Alto·London1964: 149-151
        • Ohye C
        Motor disturbances by thalamic lesion—motor thalamus (in Japanese).
        Shinkei Kenkyu no Shinpo (Tokyo). 1988; 32: 498-508