This paper is only available as a PDF. To read, Please Download here.
We divided cases of severe athetoid cerebral palsy originating perinatally into two
groups neuropathologically, the “globo-Luysian group” (GL) and the “thalamo-putaminal
group” (TP). The major abnormal sites in GL were the pallidum and subthalamic nucleus,
and in TP the thalamus and putamen. The lesions in TP were more widespread and frequently
accompanied by fibrillary gliosis in the central gray matter of the midbrain, and
subthalamic nuclei were dominantly devastated. Concerning the etiology, GL and TP
were related to perinatal severe jaundice and neonatal asphyxia, respectively. The
patients in TP showed lower mental ability and suffered from more intractable convulsions
than those in GL. In GL, rigidospasticity was frequently demonstrated with fluctuation
of athetoid movements, while in TP various abnormalities of muscle tone were observed,
with rather restricted athetosis.
Key words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Brain and DevelopmentAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Athetotic syndrome.in: Vinken PJ Bruyn GW Handbook of clinical neurology, Vol 6. Diseases of the basal ganglia. North-Holland Publ Co., Amsterdam1968: 440-475
- Problems related to cerebral palsy [5] — pathological study of cerebral palsy (in Japanese).Sogo Rihabiriteishon (Tokyo). 1979; 7: 877-888
- A new classification of cerebral palsy based on neurophysiologic considerations.Confin Neurol. 1965; 25: 378-392
- Pathological studies of the severe physically and mentally handicapped with special reference to pathological changes of the thalamus (in Japanese).Shinkei Kenkyu no Shinpo (Tokyo). 1973; 17: 93-105
- Thalamic lesions in the developmental disabilities—focusing on the cases of brain injury sustained in the perinatal period.in: Abstracts of the 10th International Congress of Neuropathology, Stockholm1986: 285
- A neuropathological study of severe mental retardation.Congenital Anomalies (Nagoya). 1983; 23: 445-459
- Neuropathology of the brainstem in age-dependent epileptic encephalopathy—especially of cases with infantile spasms.Brain Dev (Tokyo). 1986; 8: 443-449
- An etiologic and diagnostic study of cerebral palsy—a preliminary report.J Pediatr. 1964; 65: 270-293
- Some factors involved in the thalamic control of spontaneous barbiturate spindles.J Neurophysiol. 1967; 192: 257-281
- Atlas of electroencephalography, Vol 3. Neurological and psychiatric disorders. Addison-Wesley Publishing Company, Massachusetts·Palo Alto·London1964: 149-151
- Motor disturbances by thalamic lesion—motor thalamus (in Japanese).Shinkei Kenkyu no Shinpo (Tokyo). 1988; 32: 498-508
Article info
Publication history
Accepted:
December 12,
1990
Received:
November 21,
1989
Identification
Copyright
© 1991 Published by Elsevier Inc.
