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The early development of myelination was studied by means of myelin basic protein
(MBP) and luxol fast blue (LFB) stainings of large sections of the cerebral hemispheres.
Myelination first occurs in the globus pallidus, pallidothalamic fibers of the posterior
internal capsule and the thalamus at 25 weeks, which may be related to the cellular
maturation in the globus pallidus and thalamus. Then myelination is observed in the
striatum, and precentral and postcentral gyri at 35 weeks, and the anterior internal
capsule and optic radiation at 37 weeks. Immunoreactivity with MBP is observed earlier
and more strongly in the early myelination period than that with LFB. Thus, MBP may
play an important role in myelination and its delay. The macroscopic positivity as
to MBP as well as LFB staining may be related to the development of high signal intensity
observed in a T1-weighted magnetic resonance imaging, which was observed 1 to 3 months
after the first microscopic appearance of myelin.
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Article info
Publication history
Accepted:
October 25,
1991
Received:
May 24,
1991
Identification
Copyright
© 1992 Published by Elsevier Inc.
