This paper is only available as a PDF. To read, Please Download here.
The early development of myelination was studied by means of myelin basic protein (MBP) and luxol fast blue (LFB) stainings of large sections of the cerebral hemispheres. Myelination first occurs in the globus pallidus, pallidothalamic fibers of the posterior internal capsule and the thalamus at 25 weeks, which may be related to the cellular maturation in the globus pallidus and thalamus. Then myelination is observed in the striatum, and precentral and postcentral gyri at 35 weeks, and the anterior internal capsule and optic radiation at 37 weeks. Immunoreactivity with MBP is observed earlier and more strongly in the early myelination period than that with LFB. Thus, MBP may play an important role in myelination and its delay. The macroscopic positivity as to MBP as well as LFB staining may be related to the development of high signal intensity observed in a T1-weighted magnetic resonance imaging, which was observed 1 to 3 months after the first microscopic appearance of myelin.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Brain and Development
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The myelogenetic cycles of regional maturation of the brain.in: Minkowski A Regional development of the brain in early life. Blackwell, Oxford·Edinburgh1967: 3-10
- Myelinated tracts: Growth patterns.in: Gilles FH Leviton A Dooling EC The developing human brain. Growth and epidemiologic neuropathology. John Wright-PSG Inc, Boston·Bristol·London1983: 117-183
- Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination.J Neuropathol Exp Neurol. 1987; 46: 283-301
- Developmental features of the neonatal brain: MR imaging. Part I. Gray-white matter differentiation and myelination.Radiology. 1987; 162: 223-229
- Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T.Radiology. 1988; 166: 173-180
- Normal development of the neonatal and infant brain.in: Barkovich AJ Pediatric neuroimaging. Raven Press, New York1990: 5-34
- Gyral development of the human brain.Ann Neurol. 1977; 1: 86-93
- Gestational development of the brain.Arch Pathol Med. 1977; 101: 192-195
- Quelques aspects anatomiques du development cerebral.Bio Neonat. 1962; 4: 126-153
- Gross and microscopic development of the central nervous system.in: Friede RL Developmental neuropathology. 2nd ed. Springer Verlag, Berlin1989: 2-20
- Neuronal proliferation, migration, organization, and myelination.in: Volpe JJ Neurology of the newborn. 2nd ed. WB Saunders Co, Philadelphia1987: 33-68
- Human thalamus. An anatomical, developmental and pathological study. II. Development of the human thalamic nuclei.J Comp Neurol. 1954; 100: 63-97
- In vitro carboxymethylation of myelin basic protein.Neurosci Res. 1986; 4: 143-151
- Fine structure of the central meylin sheath in the myelin deficient mutant shiverer mouse, with special reference to the pattern of myelin formation by oligodendroglia.Brain Res. 1981; 219: 85-94
Accepted: October 25, 1991
Received: May 24, 1991
© 1992 Published by Elsevier Inc.