Abstract
To investigate the changes of regional cerebral blood flow (rCBF) in early-onset anorexia
nervosa (AN) before and after weight gain, we examined resting rCBF using single photon
emission computed tomography (SPECT) with [123I]iodoamphetamine (123I-IMP). Ten female children with AN (mean age 13.2 years old) participated in this study. SPECT examinations were performed in all patients
twice at the beginning of treatment and after weight gain. The mean body mass index
(BMI) was changed from 13.1 to 16.6 during 4 months treatment period. Automatic voxel-based analysis of the images was carried
out using statistical parametric mapping (SPM) software. Relatively increased rCBF
in the bilateral parietal lobe and limbic lobe including the posterior cingulate cortex
(PCC) were observed after weight gain in early-onset AN. There was no significant
decrease in the rCBF after weight gain. A significant positive correlation was observed
between BMI and rCBF in the right thalamus, right parietal lobe, and right cerebellum.
These results suggested that weight gain during the process of recovery from early-onset
AN might activate specific brain regions which are possibly relevant to the pathophysiological
aspects of the disorder.
Keywords
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Article info
Publication history
Published online: October 30, 2009
Accepted:
September 27,
2009
Received in revised form:
September 17,
2009
Received:
February 16,
2009
Identification
Copyright
© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
