Abstract
Resting-state functional MRI (fMRI) could be an advantageous choice for clinical applications
by virtue of its clinical convenience and non-invasiveness. Without explicit stimulus,
resting-state brain activity patterns cannot be obtained using any model-driven method.
In this study, we advanced a measure named resting-state activity index (RSAI) to
evaluate the resting-state brain activities. Using RSAI, we first investigated the
resting-state brain activity patterns in normal adolescents to test the validity of
this RSAI measure. Then we compared the resting-state brain activity patterns of Attention
deficit hyperactivity disorder (ADHD) patients to those of their matched controls.
According to the resultant brain activity patterns, we suggest that RSAI could be
an applicable measure to evaluate resting-state brain activities. As compared to the
controls, the ADHD patients exhibited more significant resting-state activities in
basic sensory and sensory-related cortices. This finding was in accordance with ADHD
symptoms of inattention.
Keywords
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Article info
Publication history
Accepted:
October 13,
2007
Received in revised form:
September 20,
2007
Received:
May 26,
2007
Identification
Copyright
© 2007 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
