Abstract
Serial study using MR imaging and 1H-MR spectroscopy (1H-MRS) of unidentified bright objects (UBO) in a 9-year-old boy with neurofibromatosis
type 1 (NF1) is described. UBO was indicated in the left globus pallidum at 3 years
old, then appeared in the right globus pallidum at 5 years old along with left hemiconvulsion.
These UBO gradually disappeared over several years. On 1H-MRS, the ratios of N-acetylaspartate (NAA)/creatine and that of choline/creatine were each mildly reduced
in the UBO. These ratios improved in parallel with disappearance of the UBO. In addition,
elevation of the lactate/lipid peak was shown in UBO during the early stage, however,
it disappeared in the latter. The longitudinal follow-up using MR image and 1H-MRS was useful for metabolic evaluation of UBO in patients with NF1.
Keywords
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Article info
Publication history
Accepted:
February 21,
2005
Received in revised form:
February 2,
2005
Received:
October 28,
2004
Identification
Copyright
© 2005 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
