Advertisement

Serial MR imaging and 1H-MR spectroscopy of unidentified bright objects in a case of neurofibromatosis type 1

      Abstract

      Serial study using MR imaging and 1H-MR spectroscopy (1H-MRS) of unidentified bright objects (UBO) in a 9-year-old boy with neurofibromatosis type 1 (NF1) is described. UBO was indicated in the left globus pallidum at 3 years old, then appeared in the right globus pallidum at 5 years old along with left hemiconvulsion. These UBO gradually disappeared over several years. On 1H-MRS, the ratios of N-acetylaspartate (NAA)/creatine and that of choline/creatine were each mildly reduced in the UBO. These ratios improved in parallel with disappearance of the UBO. In addition, elevation of the lactate/lipid peak was shown in UBO during the early stage, however, it disappeared in the latter. The longitudinal follow-up using MR image and 1H-MRS was useful for metabolic evaluation of UBO in patients with NF1.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Griffiths P.D.
        • Blaser S.
        • Mukonoweshuro W.
        • Armstrong D.
        • Milo-Mason G.
        • Cheung S.
        Neurofibromatosis bright objects in children with neurofibromatosis type 1: a proliferative potential?.
        Pediatrics. 1999; 104: e49
        • DiMario Jr, F.J.
        • Ramsby G.R.
        • Burleson J.A
        Brain morphometric analysis in neurofibromatosis 1.
        Arch Neurol. 1999; 56: 1343-1346
        • DeBella K.
        • Poskitt K.
        • Szudek J.
        • Friedman J.M.
        Use of ‘unidentified bright objects’ on MRI for diagnosis of neurofibromatosis 1 in children.
        Neurology. 2000; 54: 1646-1651
        • Dipaolo D.P.
        • Zimmerman R.A.
        • Rorke L.B.
        • Zachai E.H.
        • Bilaniuk L.T.
        • Yachnis A.T.
        Neurofibromstosis type 1: pathologic substrate of high intensity foci in the brain.
        Radiology. 1995; 195: 721-724
        • Mizuno S.
        • Takahashi Y.
        • Kato Z.
        • Goto H.
        • Kondo N.
        • Hoshi H.
        Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
        Acta Neurol Scand. 2000; 102: 175-178
        • Imamura A.
        • Orii K.E.
        • Mizuno S.
        • Hoshi H.
        • Konda T.
        MR imaging and 1H-MR spectroscopy in a case of juvenile Alexander disease.
        Brain Dev. 2002; 24: 723-726
        • Korf B.R.
        • Carrazana E.
        • Holmes G.L.
        Patterns of seizures observed in association with neurofibromatosis 1.
        Epilepsia. 1993; 34: 616-620
        • Jones A.P.
        • Gunawardena W.J.
        • Coutinho C.M.
        1H MR spectroscopy evidence for the varied nature of asymptomatic focal brain lesions in neurofibromatosis type 1.
        Neuroradiology. 2001; 43: 62-67
        • Wilkinson I.D.
        • Griffiths P.D.
        • Wales J.K.
        Proton magnetic resonance spectroscopy of brain lesions in children with neurofibromatosis type 1.
        Magn Reson Imaging. 2001; 19: 1081-1089
        • Alkan A.
        • Sarac K.
        • Kutlu R.
        • Yakinci C.
        • Sigirci A.
        • Aslan M.
        Proton MR spectroscopy features of normal appearing white matter in neurofibromatosis type 1.
        Magn Reson Imaging. 2003; 21: 1049-1053
        • Davie C.A.
        • Hawkins C.P.
        • Barker G.J.
        • Brennan A.
        • Tofts P.S.
        • Miller D.H.
        Detection of myelin breakdown products by proton magnetic resonance spectroscopy.
        Lancet. 1993; 341: 630-631