Abstract
Vitamin B12 deficiency can cause serious developmental regression, hypotonia and cerebral atrophy
in infants. We report a 6-month-old infant, with insidious developmental regression
and brain atrophy showed by CT scan, secondarily to vitamin B12 deficiency. His mother was a strict vegetarian and the patient was exclusively breastfed.
The clinical symptoms and the brain CT were normalized after vitamin B12 administration.
Keywords
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References
- The neurological syndrome of infantile cobalamin deficiency: developmental regression and involuntary movements.Mov Disord. 1997; 12: 39-46
- Vitamin B12 deficiency in children and adolescents.J Pediatr. 2001; 138: 10-17
- Long-term neurologic consequences of nutritional vitamin B 12 deficiency in infants.J Pediatr. 1992; 121: 710-714
- Vitamin B 12 deficiency: a cause of abnormal movements in infants.Pediatrics. 1997; 99: 255-256
- Involuntary movements in infantile cobalamin deficiency appearing after treatment.Pediatr Neurol. 2001; 25: 81-83
- Neurologic aspects of cobalamin deficiency.Medicine. 1991; 70: 229-245
- Neurological effects of malabsorption and vitamin deficiency.in: Samuels M.A. Feske S. Office practice of neurology. Churchill Livingstone, New York, NY1996: 1280
- Diagnosis of cobalamin deficiency: the old and the new.Br J Haematol. 1997; 97: 695-700
- Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.Nature. 1975; 258: 173-174
- Persistence of neurological damage induced by dietary vitamin B12 deficiency in infancy.Arch Dis Child. 1997; 77: 137-139
Article info
Publication history
Accepted:
February 9,
2005
Received in revised form:
February 8,
2005
Received:
February 3,
2004
Identification
Copyright
© 2005 Elsevier B.V. Published by Elsevier Inc. All rights reserved.