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Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring

  • Eun-Kyung Kim
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Exercise Physiology, Graduate School, Korea University, #5-1 Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea
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  • Myoung-Hwa Lee
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Exercise Physiology, Graduate School, Korea University, #5-1 Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea
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  • Hong Kim
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Exercise Physiology, Graduate School, Korea University, #5-1 Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea
    Search for articles by this author
  • Young-Je Sim
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Exercise Physiology, Graduate School, Korea University, #5-1 Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea
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  • Mal-Soon Shin
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Exercise Physiology, Graduate School, Korea University, #5-1 Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea
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  • Sam-Jun Lee
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Exercise Physiology, Graduate School, Korea University, #5-1 Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea
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  • Hye-Young Yang
    Affiliations
    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
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  • Hyun-Kyung Chang
    Affiliations
    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
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  • Taeck-Hyun Lee
    Affiliations
    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
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  • Mi-Hyeon Jang
    Affiliations
    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
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  • Min-Chul Shin
    Affiliations
    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
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  • Hee-Hyuk Lee
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
    Search for articles by this author
  • Chang-Ju Kim
    Correspondence
    Corresponding author. Address: Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea. Tel.: +82 2 961 0407; fax: +82 2 964 2195.
    Affiliations
    College of Medicine, Kohwang Medical Research Institute, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

    Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
    Search for articles by this author

      Abstract

      Maternal ethanol consumption during pregnancy has a detrimental effect on the central nervous system (CNS) development of fetus. 5-Hydroxytryptamine (5-HT) is an important neurotransmitter and/or neuromodulator in the mammalian CNS. Tryptophan hydroxylase (TPH) is the rate limiting enzyme of 5-HT synthesis. Ethanol is known to induce neuropsychiatric disorders by alteration of the central serotonergic system. In the present study, the effects of maternal ethanol intake on the 5-HT synthesis and the TPH expression in the dorsal raphe of rat offspring were investigated. The present results show that the synthesis of 5-HT and the expression of TPH in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake and that the suppressive effect of alcohol was more potent in the 5 weeks old rat pups compared to the 3 weeks old rat pups. Based on the present study, it can be suggested that the pathogenesis of ethanol-induced neuropsychological disorders involves ethanol-induced suppression on the 5-HT synthesis and the TPH expression in the dorsal raphe of offspring.

      Keywords

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