Abstract
The authors report an infant with congenital hemiplegia associated to heterozygousity
for factor V Leiden. Prenatal stroke in the left cerebral hemisphere was diagnosed
by ultrasonography at the 28th week of pregnancy, and followed up until birth. Although
neonatal neurologic examination was normal, a moderate right hemiparesis developed
along the 1st months of life. Coagulation studies performed in the neonatal period
and at the age of 18 months revealed activated protein C resistance due to factor
V Leiden mutation (R506Q). There are some previous reports of stroke associated to
this mutation in near or at term neonates, but to our knowledge this is the stroke
detected at the most early stage of fetal development.
Keywords
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Article info
Publication history
Accepted:
October 27,
2004
Received in revised form:
October 27,
2004
Received:
February 23,
2004
Identification
Copyright
© 2004 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
