Abstract
Cerebral mycotic aneurysms are one of the most serious complications of bacterial
endocarditis but the mechanism underlying cerebral aneurysms is unclear. We reported
the cytokine levels in a cerebral mycotic aneurysm in a child with Down's syndrome.
The patient was a 12-year-old female. She was diagnosed as having Down's syndrome
and congenital heart disease consisting of an endocardial cushion defect at birth.
She underwent a radical operation at 9 years but mitral valve regurgitation remained.
She was hospitalized with high fever, vomiting, loss of activity and gait disturbance.
Neurological examination revealed facial palsy and hemiparesis on the left side. Cytokines
such as IL-6, TNF-α, sTNFR1 and sE-selectin were elevated in blood, and IL-6, TNF-α
and sTNFR1 in cerebrospinal fluid. T2-weighted MRI disclosed a low intensity area
in the right Sylvian sulcus. MR angiography showed an aneurysm of the right middle
cerebral artery. We think that cytokines and the formation abnormality of collagen
fibers are related to the production of aneurysms.
Keywords
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Article info
Publication history
Accepted:
September 15,
2004
Received in revised form:
June 30,
2004
Received:
October 8,
2003
Identification
Copyright
© 2004 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
