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Buspirone in Rett syndrome respiratory dysfunction

  • Author Footnotes
    1 Rua Visconde de Inhaúma 308 (92), ZIP 04145-030, SP/SP, Brazil.
    Daniela K. Andaku
    Footnotes
    1 Rua Visconde de Inhaúma 308 (92), ZIP 04145-030, SP/SP, Brazil.
    Affiliations
    Santo Amaro University Physical Therapy School, São Paulo, Brazil
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  • Author Footnotes
    2 Av. BR Campos Gerais, 193 (62), ZIP 05684-000, SP/SP, Brazil.
    Marcos T. Mercadante
    Footnotes
    2 Av. BR Campos Gerais, 193 (62), ZIP 05684-000, SP/SP, Brazil.
    Affiliations
    Pervasive Developmental Disorder Program, Mackenzie Presbyterian University, São Paulo, Brazil
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  • José Salomão Schwartzman
    Correspondence
    Corresponding author. Address: Rua França Pinto, 941 ZIP 04016-034, SP/SP Brazil. Fax: +55 11 5571 7743.
    Affiliations
    Pervasive Developmental Disorder Program, Mackenzie Presbyterian University, São Paulo, Brazil
    Search for articles by this author
  • Author Footnotes
    1 Rua Visconde de Inhaúma 308 (92), ZIP 04145-030, SP/SP, Brazil.
    2 Av. BR Campos Gerais, 193 (62), ZIP 05684-000, SP/SP, Brazil.

      Abstract

      This study details a case of Rett Syndrome where the patient's respiratory dysfunction was improved after buspirone was administered. Polygraphic studies in the waking state, before and after treatment with 5 mg of buspirone twice a day, were obtained. Breathing movements, oxygen saturation and end-tidal carbon were monitored. Average oxygen saturation increased from 86.9 to 91%, and the period of saturation below 90% was reduced by 42.2%. The oxygen saturation improvement observed in this case suggests that buspirone might be useful in treating respiratory dysfunction associated with Rett Syndrome. Controlled clinical trials are needed to provide more evidence.

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