We report a 3-year-old patient who presented a secondary acute neurological deterioration clinically characterized by a partial Kluver–Bucy syndrome, 1 month after the onset of herpes simplex encephalitis. This episode is unlikely due to continuation or resumption of cerebral viral replication but might be related to an immune-inflammatory process. In children, postinfectious immune-mediated encephalitis occuring after HSE are usually clinically characterized by choreoathetoid movements. This type of movement disorder was, however, not observed in this patient. On the basis of this case and a review of the literature, we hypothesize the existence of a spectrum of secondary immune-mediated process triggered by herpes simplex virus cerebral infection ranging from asymptomatic cases with diffuse white matter involvement to secondary acute neurological deteriorations with or without extrapyramidal features.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Brain and Development
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Herpes simplex encephalitis relapses in children: differentiation of two neurologic entities.Neurology. 2003; 61: 241-243
- Kluver Bucy syndrome in young children.Clin Neurol Neurosurg. 1998; 100: 254-258
- Postinfectious autoimmune-mediated encephalitis eight months after herpes simplex encephalitis.Eur Neurol. 2003; 50: 54-56
- Post-infectious encephalomyelitis after successful treatment of herpes simplex encephalitis with adenine arabinoside: ultrastructural observations.N Engl J Med. 1979; 300: 1089-1093
- Asymptomatic self-limiting white matter lesions in the chronic phase of herpes simplex encephalitis.Brain Dev. 2002; 24: 300-303
- Diffuse white matter lesions associated with herpes simplex encephalitis as observed on magnetic resonance imaging.Brain Dev. 1996; 18: 150-152
- A case of herpes simplex encephalitis with cerebral white matter lesion after acyclovir administration.No To Hattatsu. 1990; 22: 488-493
- Acute disseminated encephalomyelitis.Neurology. 2002; 59: 1224-1231
- Herpes simplex virus type I (HSV I)-induced multifocal central nervous system (CNS) demyelination in mice.J Neuropathol Exp Neurol. 1992; 51: 432-439
- Herpes simplex virus encephalitis: chronic progressive cerebral MRI changes despite good clinical recovery and low viral load—an experimental mouse study.Eur J Neurol. 1999; 6: 531-538
- Relapse of herpes simplex encephalitis [see comments].J Child Neurol. 1995; 10: 363-368
- Glial cell responses to herpesvirus infections: role in defense and immunopathogenesis.J Infect Dis. 2002; 186: S171-S179
Accepted: July 22, 2004
Received in revised form: June 9, 2004
Received: January 20, 2004
© 2004 Elsevier B.V. Published by Elsevier Inc. All rights reserved.