Abstract
In patients with subacute sclerosing panencephalitis, clinical stages defined according
to Jabbour correlate strongly with frontal lobe dysfunctions. Nonquantitative radiologic
investigations in these patients have confirmed cerebral atrophy without identifying
predominantly affected regions. We addressed this issue over an 8-year-old boy's course
using volumetry based on three-dimensional T1-weighted gradient echo magnetic resonance
imaging. Seven normal 6–12-year-old subjects served as controls. Whole-brain volume
declined as Jabbour stage advanced from I to III. Frontal lobe volume and frontal-to-whole-brain
volume ratios fell significantly as clinical stage progressed. Thus, cerebral atrophy
in this SSPE patient was predominantly frontal, and paralleled clinical progression.
Keywords
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Article info
Publication history
Accepted:
May 9,
2004
Received in revised form:
March 29,
2004
Received:
November 26,
2003
Identification
Copyright
© 2004 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
