Advertisement

Preface

      It is well known that patients with chromosomal aberrations tend to associate with epilepsy in a higher frequency in comparison with general population, and that, notwithstanding the above general trend, there are a considerable difference in the incidences of epilepsy association among various chromosomal aberrations; in some the rate is nearly the same or only slightly increased, while in others the association is extremely frequent up to such a level that physicians could easily suspect a potential critical role of a particular chromosomal abnormality in causing epileptic phenotype. In the latter case, hunting for the epilepsy-causing gene is much easier, because the candidate gene is highly likely to locate in an already delineated specific area of a chromosome (deletion, duplication, translocation, etc.). Thus, it will be an efficient research strategy to identify such chromosomopathy syndromes with high association of epilepsy as a research target.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect