It is well known that patients with chromosomal aberrations tend to associate with
epilepsy in a higher frequency in comparison with general population, and that, notwithstanding
the above general trend, there are a considerable difference in the incidences of
epilepsy association among various chromosomal aberrations; in some the rate is nearly
the same or only slightly increased, while in others the association is extremely
frequent up to such a level that physicians could easily suspect a potential critical
role of a particular chromosomal abnormality in causing epileptic phenotype. In the
latter case, hunting for the epilepsy-causing gene is much easier, because the candidate
gene is highly likely to locate in an already delineated specific area of a chromosome
(deletion, duplication, translocation, etc.). Thus, it will be an efficient research
strategy to identify such chromosomopathy syndromes with high association of epilepsy
as a research target.
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Article info
Publication history
Accepted:
April 12,
2004
Identification
Copyright
© 2004 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
