Preface| Volume 27, ISSUE 2, P79, March 2005

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      It is well known that patients with chromosomal aberrations tend to associate with epilepsy in a higher frequency in comparison with general population, and that, notwithstanding the above general trend, there are a considerable difference in the incidences of epilepsy association among various chromosomal aberrations; in some the rate is nearly the same or only slightly increased, while in others the association is extremely frequent up to such a level that physicians could easily suspect a potential critical role of a particular chromosomal abnormality in causing epileptic phenotype. In the latter case, hunting for the epilepsy-causing gene is much easier, because the candidate gene is highly likely to locate in an already delineated specific area of a chromosome (deletion, duplication, translocation, etc.). Thus, it will be an efficient research strategy to identify such chromosomopathy syndromes with high association of epilepsy as a research target.
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