The authors report a 4-year-old girl who developed brain stem glioblastoma. Meningeal irritation was present at onset. Magnetic resonance imaging revealed intracranial and intraspinal leptomeningeal dissemination, which progressed faster than the original tumor. Multiple large cysts developed at the interhemispheric and prepontine cisterns, resulting in progressive obstructive hydrocephalus. The patient survived only 5 months after presentation. Histology was verified by autopsy.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Brain and Development
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Pattern of recurrence in brain stem gliomas: evidence for craniospinal dissemination.Int J Radiat Oncol Bio Phys. 1998; 40: 677-680
- Pediatric brain stem gliomas: an update.Child's Nerve Syst. 1998; 14: 167-173
- Treatment of Children with newly diagnosed brain stem gliomas with intravenous recombinant β-interferon and hyperfractionated radiation therapy.Cancer. 1996; 77: 2150-2156
- Chemotherapy for brain stem gliomas.Child's Nerve Syst. 1999; 15: 545-553
- Primitive neuroectodermal tumor of the brainstem: investigation of seven cases.Pediatrics. 2000; 106: 1045-1053
- Brainstem glioma: clinical manifestations of meningeal gliomatosis.Ann Neurol. 1983; 14: 177-182
- Brain stem and spinal metastasis of supratentorial glioblastoma multiforme: a clinical series.Neurosurgery. 1990; 27: 516-522
- Infratentorial glioblastoma: the role of neuraxis irradiation.Int J Radiat Oncol Bio Phys. 1982; 8: 999-1003
- Low-grade astrocytoma with neuraxis dissemination at diagnosis.J Neurosurg. 1995; 83: 67-71
- Hydrocephalus and intracranial tumor.J Neurosurg. 1981; 55: 174-182
Accepted: March 11, 2004
Received in revised form: March 10, 2004
Received: September 24, 2003
© 2004 Published by Elsevier Inc.