Case report| Volume 27, ISSUE 1, P58-61, January 2005

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Brain stem glioblastoma with multiple large cyst formation and leptomeningeal dissemination in a 4-year-old girl


      The authors report a 4-year-old girl who developed brain stem glioblastoma. Meningeal irritation was present at onset. Magnetic resonance imaging revealed intracranial and intraspinal leptomeningeal dissemination, which progressed faster than the original tumor. Multiple large cysts developed at the interhemispheric and prepontine cisterns, resulting in progressive obstructive hydrocephalus. The patient survived only 5 months after presentation. Histology was verified by autopsy.


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        • Donahue B.
        • Allen J.
        • Siffert J.
        • Rosovsky M.
        • Pint R.
        Pattern of recurrence in brain stem gliomas: evidence for craniospinal dissemination.
        Int J Radiat Oncol Bio Phys. 1998; 40: 677-680
        • Rubin G.
        • Michowitz S.
        • Horev G.
        • Herscovici Z.
        • Cohen I.J.
        • Shuper A.
        • et al.
        Pediatric brain stem gliomas: an update.
        Child's Nerve Syst. 1998; 14: 167-173
        • Packer R.J.
        • Prados M.
        • Phillips M.
        • Nicolson H.S.
        • Boyett M.N.
        • Goldwon J.
        • et al.
        Treatment of Children with newly diagnosed brain stem gliomas with intravenous recombinant β-interferon and hyperfractionated radiation therapy.
        Cancer. 1996; 77: 2150-2156
        • Freeman C.R.
        • Perilongo G.
        Chemotherapy for brain stem gliomas.
        Child's Nerve Syst. 1999; 15: 545-553
        • Zagzag D.
        • Miller D.C.
        • Knopp E.
        • Farmer J.P.
        • Lee M.
        • Shahriar B.
        • et al.
        Primitive neuroectodermal tumor of the brainstem: investigation of seven cases.
        Pediatrics. 2000; 106: 1045-1053
        • Packer R.J.
        • Allen J.
        • Nielsen S.
        • Petito C.
        • Deck M.
        • Jereb B.
        Brainstem glioma: clinical manifestations of meningeal gliomatosis.
        Ann Neurol. 1983; 14: 177-182
        • Vertosick F.T.
        • Selker R.G.
        Brain stem and spinal metastasis of supratentorial glioblastoma multiforme: a clinical series.
        Neurosurgery. 1990; 27: 516-522
        • Kopelson G.
        • Linggood R.
        Infratentorial glioblastoma: the role of neuraxis irradiation.
        Int J Radiat Oncol Bio Phys. 1982; 8: 999-1003
        • Gajjar A.
        • Bhargava R.
        • Jenkins J.J.
        • Heideman R.
        • Sanford R.A.
        • Langston J.W.
        Low-grade astrocytoma with neuraxis dissemination at diagnosis.
        J Neurosurg. 1995; 83: 67-71
        • Raimondi A.J.
        • Tomita T.
        Hydrocephalus and intracranial tumor.
        J Neurosurg. 1981; 55: 174-182