Abstract
We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic
at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of
CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal
myelination without any gray matter abnormalities. In the differential diagnosis of
patients with abnormal white matter lesions and sensorineural hearing loss, one should
consider congenital CMV infection. When investigating the etiology of patients with
behavioral problems, migrational disorder, or white matter disease, PCR analysis of
CMV DNA using blood stored on Guthrie cards might be helpful.
Keywords
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Article info
Publication history
Accepted:
May 24,
2002
Received in revised form:
May 13,
2002
Received:
February 25,
2002
Identification
Copyright
© 2002 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
