Abstract
We prospectively investigated the relation among cerebral blood flow, periventricular
leukomalacia (PVL) and hypocarbia using Doppler ultrasonography in 53 preterm infants
with gestational age between 27 and 34 weeks who required mechanical ventilation during
the first 72 h of life. Cerebral blood flow of pericallosal artery was assessed by
Doppler ultrasonography at the first and the third day of life. Mean velocity (MV)
and Resistance index (RI) of anterior cerebral artery were calculated from the data
obtained by Doppler ultrasonography. The diagnosis of PVL was made in 12 infants on
the basis of the results of ultrasonography and MRI. Hypocarbia was judged as positive
when both arterial blood gas analyses before and after the ultrasonography revealed
PaCO2 values <25 mmHg. On the first day of life, RI was 0.62±0.022 in infants with PVL
and 0.71±0.014 in those without PVL. On the third day of life, RI was 0.60±0.032 in
infants with PVL and 0.66±0.013 in those without PVL. There was a significant difference
in RI between the two groups at either point. MV was not significantly different between
the two groups at either point. There was no significant difference in RI or MV between
infants with and without hypocarbia at either point. RI was significantly lower in
infants with PVL during the first 72 h of life, which is suggestive of vasoparalysis
in such infants at the level of major cerebral arteries. However, RI or MV was no
different between infants with and without hypocarbia.
Keywords
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Article info
Publication history
Accepted:
May 29,
2002
Received in revised form:
May 28,
2002
Received:
February 22,
2002
Identification
Copyright
© 2002 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
