Abstract
In patients with Rett syndrome (RS), a peculiar type of disturbance in phasic chin
muscle activity during rapid-eye-movement sleep (REMS) (e.g. an elevation of phasic
inhibition index (PII) without an affection of tonic inhibition index (TII)) has been
reported. The similar disturbance in REMS was reported not only in child patients
with infantile spasms, severe myoclonic epilepsy in infancy (SMEI), severe nocturnal
enuresis, and autism but also in adult patients with Parkinson's disease (PD). Except
for SMEI and PD, patients with the other four clinical entities including RS could
express autistic tendency. Since the responsible lesion for the occurrence of an elevation
of PII with a normal TII value is likely to be in the pontine tegmentum, this subcortical
structure is hypothesized to be involved in the appearance of autistic tendency.
Keywords
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© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
