Original article| Volume 23, SUPPLEMENT 1, S90-S93, December 2001

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Cerebrolysin therapy in Rett syndrome: clinical and EEG mapping study


      Based on the suggestion that nerve growth factor plays a core role in the brain maturation process, which is altered in Rett syndrome, we investigate the influence of Cerebrolysin — the brain-derived peptidergic drug — on motor and higher cortical functions in Rett syndrome girls. The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness, and included both clinical and quantitative EEG evaluations before and after Cerebrolysin treatment. After Cerebrolysin treatment, increases in the behavioral activity, attention level, motor functions, and non-verbal social communication have been shown in Rett syndrome patients. EEG parameters after Cerebrolysin treatment also changed towards normal values, indicating an improvement of the brain functional state. EEG changes included: decrease of theta activity over all cortical regions, increase of beta activity in the frequency band 13–15 Hz, and some restoration of the occipital alpha rhythm (in the narrow 8–9 Hz band). The data obtained suggested possible perspectives of Cerebrolysin in complex therapy of Rett syndrome.


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        • Belichenko P.V.
        • Hagberg B.
        • Dahistrom A.
        Morphological studies of neocortical areas in Rett syndrome.
        Acta Neuropathol. 1997; 93: 50-61
        • Armstrong D.
        The neuropathology of the Rett syndrome.
        Brain Dev. 1992; 14: 89
        • Riikonen R.
        • Vanhala R.
        Levels of cerebrospinal fluid nerve-growth factor differ in infantile autism and Rett syndrome.
        Dev Med Child Neurol. 1999; 41: 148-152
        • Levi-Montalcini R.
        • Aloe L.
        • Alleva E.
        A role for nerve growth factor in nervous, endocrine and immune systems.
        Prog Neuroendocrinimmunol. 1990; 3: 1-10
        • Windisch M.
        • Gschanes A.
        • Hutter-Paier B.
        Neurotrophic activities and therapeutic experience with a brain derived peptide preparation.
        J Neural Transm. 1998; 53: 289-298
        • Hutter-Paier B.
        • Steiner E.
        • Windisch M.
        Cerebrolysin protects isolated cortical neurons from neurodegeneration after brief histotoxic hypoxia.
        J Neural Transm. 1998; 53: 351-361
        • Bashina V.M.
        • Gorbachevskaya N.L.
        • Simashkova N.V.
        • Yakupova L.P.
        • Skvortsov I.A.
        • Osipenko T.N.
        • et al.
        Severe forms of early childhood autism: new approach to pathogenesis.
        Eur Child Adolesc Psychiatry. 1997; 6: 18
        • Ruther E.
        • Ritter R.
        • Apecechea M.
        • Freytag S.
        • Windish M.
        Efficacy of peptidergic nootropic drug Cerebrolysin in patients with senile dementia of Alzheimer type.
        Pharmacopsychiatry. 1994; 27: 32-40
        • Lopes da Silva F.
        Neural mechanisms underlying brain waves: from neuronal membranes to networks.
        Electroenceph clin Neurophysiol. 1991; 79: 81-93
        • Niedenneyer E.
        • Naidu S.
        • Plate C.
        Unusual EEG theta rhythms over central region in Rett syndrome: considerations of the underlying dysfunction.
        Clin Electroencephalogr. 1997; 28: 36-43
        • Gorbachevskaya N.L.
        • Zavadenko N.N.
        • Yakupova L.P.
        • Sorokin A.B.
        • Suvorinova N.Ur.
        • Grigoneva N.V.
        • et al.
        EEG study of child hyperactivity.
        Hum Physiol. 1996; 22: 49-54
        • Ishizaki A.
        • Inoue Y.
        • Sasaki H.
        • Fukuyama Y.
        Longitudinal observation of electroencephalograms in the Rett syndrome.
        Brain Dev. 1989; 11: 407-412
        • Gorbachevskaya N.L.
        • Bashina V.M.
        • Gratchev V.V.
        • Yakupova L.P.
        • Simashkova N.V.
        • Iznak A.F.
        The EEG correlates of motor dysfunction in girls with Rett syndrome.
        in: New developments in child neurology. Monduzzi Editore, Bologna1998: 203-206
      1. Panuishkina S. EEG dynamics of neurotransmitters processes in neurotic patients. Thesis Dissertation D. Med. Sci., Moscow, 2000 (In Russian).

        • Segawa M.
        Pathophysiology of Rett syndrome from the standpoint of early catecholamine disturbance.
        Eur Child Adolesc Psychiatry. 1997; 6: 56-61
        • Wenk G.L.
        • Hauss-Wegrzyniak B.
        Altered cholinergic function in the basal forebrain of girls with Rett syndrome.
        Neuropediatrics. 1999; 30: 125-129