Review article| Volume 23, ISSUE 7, P658-661, November 2001

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Zonisamide in West syndrome

  • Yasuhiro Suzuki
    Tel.: +81-725-56-1220; fax: +81-725-56-5682
    Collaborate Clinical Research Group for Pediatric Neurology, Osaka University Medical School, Osaka, Japan

    Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840, Murodo-cho, Izumi, Osaka 594-1101, Japan
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      Zonisamide (ZNS), a new antiepileptic drug developed in Japan, is being used as the initial treatment of West syndrome in some Japanese institutes. The reported response rate varied from 20 to 38%. The cryptogenic patients showed a better response than the symptomatic patients. A striking finding was that the response to ZNS is rapid; most of the children who responded did so within 1–2 weeks of starting ZNS at a dose of 4–8 mg/kg/day. No serious side effects have been reported so far. ZNS may be both effective and well tolerated for the initial treatment of selected patients with West syndrome.


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        • Jeavons P.M
        • Livet M.O
        West syndrome: infantile spasms.
        in: Roger J Bureau M Dravet Ch Dreifuss F.E Perret A Wolf P Epileptic syndromes in infancy, childhood and adolescence. 2nd ed. John Libbey, London1992: 53-65
        • Pellock J.M
        • Appleton R
        Use of new antiepileptic drugs in the treatment of child epilepsy.
        Epilepsia. 1999; 40: S29-S38
        • Appleton R.E
        • Peters A.C.B
        • Mumford J.P
        • Shaw D.E
        Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms.
        Epilepsia. 1999; 40: 1627-1633
        • Glauser T.A
        • Clark P.O
        • McGee K
        Long-term response to topiramate in patients with West syndrome.
        Epilepsia. 2000; 41: S91-S94
        • Veggiotti P
        • Cieuta C
        • Rey E
        • Dulac O
        Lamotrigine in infantile spasms.
        Lancet. 1994; 344: 1375-1376
        • Hurst D.L
        • Rolan T.D
        The use of felbamate to treat infantile spasms.
        J Child Neurol. 1995; 10: 134-136
        • Cossette P
        • Riviello J.J
        • Carmant L
        ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.
        Neurology. 1999; 52: 1691-1694
        • Johnson M.A
        • Krauss G.L
        • Miller N.R
        • Medura M
        • Paul S.R
        Visual function loss from vigabatrin: effect of stopping the drug.
        Neurology. 2000; 55: 40-45
        • Seino M
        • Ito T
        in: Engel Jr, J Pedley T.A Epilepsy: a comprehensive textbook. Lippincott-Raven, Philadelphia, PA1997: 1619-1626
        • Ito M
        Antiepileptic drug treatment of West syndrome.
        Epilepsia. 1998; 39: 38-41
        • Yagi K
        • Seino M
        Methodological requirements for clinical trials in refractory epilepsies – our experience with zonisamide.
        Prog Neuropsychopharmacol Biol Psychiatry. 1992; 16: 79-85
        • Hikima A
        • Shimizu N
        • Takizawa N
        Treatment of West syndrome with zonisamide: 13 case reports (in Japanese).
        No To Hattatsu (Tokyo). 1993; 25: S132
        • Yanagihara K
        • Imai K
        • Otani K
        • Futagi Y
        The effect of zonisamide in West syndrome (in Japanese).
        No To Hattatsu (Tokyo). 1995; 27: 500-502
        • Yanai S
        • Hanai T
        • Narazaki O
        Treatment of infantile spasms with zonisamide.
        Brain Dev. 1999; 21: 157-161
        • Suzuki Y
        • Nagai T
        • Ono J
        • Imai K
        • Otani K
        • Tagawa T
        • et al.
        Zonisamide monotherapy in newly diagnosed infantile spasms.
        Epilepsia. 1997; 38: 1035-1038
        • Kawawaki H
        • Tomiwa K
        • Shiraishi K
        • Murata R
        Efficacy of zonisamide in West syndrome (in Japanese).
        No To Hattatsu (Tokyo). 1999; 31: 263-267
        • Suzuki Y
        • Ueda H
        • Toribe Y
        • Arai H
        • Imai K
        • Fujikawa Y
        • et al.
        Zonisamide monotherapy in newly diagnosed infantile spasms (2nd report) (in Japanese).
        No To Hattatsu (Tokyo). 2000; 32: S204