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Zonisamide in West syndrome

  • Yasuhiro Suzuki
    Correspondence
    Tel.: +81-725-56-1220; fax: +81-725-56-5682
    Affiliations
    Collaborate Clinical Research Group for Pediatric Neurology, Osaka University Medical School, Osaka, Japan

    Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840, Murodo-cho, Izumi, Osaka 594-1101, Japan
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      Abstract

      Zonisamide (ZNS), a new antiepileptic drug developed in Japan, is being used as the initial treatment of West syndrome in some Japanese institutes. The reported response rate varied from 20 to 38%. The cryptogenic patients showed a better response than the symptomatic patients. A striking finding was that the response to ZNS is rapid; most of the children who responded did so within 1–2 weeks of starting ZNS at a dose of 4–8 mg/kg/day. No serious side effects have been reported so far. ZNS may be both effective and well tolerated for the initial treatment of selected patients with West syndrome.

      Keywords

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