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High-dose vitamin B6 treatment in West syndrome

  • Yasuhisa Toribe
    Correspondence
    Tel.: +81-725-56-1220; fax: +81-725-56-5682
    Affiliations
    Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health,840, Murodo-cho, Izumi, Osaka 594-1101, Japan
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      Abstract

      Approximately 10–30% of patients with West syndrome respond to high-dose vitamin B6 treatment. The response to vitamin B6 is rapid; seizures disappear within the first 2 weeks of treatment. Mild side effects, such as gastrointestinal symptoms and liver dysfunction, are observed in 40–70%, but these resolve after discontinuation or a reduction of the dosage of vitamin B6. High-dose vitamin B6 treatment is useful as a first line agent in treating West syndrome.

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