Original article| Volume 23, ISSUE 7, P570-574, November 2001

National survey of West syndrome in Taiwan

  • Chainllie Young
    Corresponding author. Department of Psychiatry, Washington University in St. Louis, 660 S. Euclide, St. Louis, MO 63110, USA. Tel.: +1-314-362-2248; fax: +1-314-362-2099
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
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  • Affiliations
    Taiwan Child Neurology Society, Room 306, Apartment 5, 3rd Floor, No. 6, Heng-yang, Taipei, Taiwan


      In the fall of 2000, the Taiwan Child Neurology Society performed a retrospective survey of West syndrome that occurred in 1998 and 1999 in Taiwan. Questionnaires were sent to the child neurologists in 15 major teaching hospitals or medical centers throughout Taiwan. There were totally 41 cases in these 2 years. Among these 41 cases, 35 had complete data and were enrolled for analysis. The male to female ratio was 1:1.19. The mean age of onset was 6.0±4.9 months old. Twenty nine percent were classified as cryptogenic and 71% were symptomatic. Adrenocorticotropic hormone (ACTH) was given to 40% of these patients. The initial response rate was 78.6% and the recurrence rate was 36.4%. For those patients not receiving ACTH, vigabatrin and valproic acid were two of the most common choices. At the final visit, 37% patients remained seizure-free, 29% were still suffering from the same seizure, and 34% changed to other seizure types. The final developmental status was normal in 14%, mildly retarded in 20%, and moderate to severely retarded in 66% of the patients.


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        • West W.J
        On a peculiar form of infantile convulsions.
        Lancet. 1841; 1: 724-725
        • Vigevano F
        • Cilio M.R
        Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study.
        Epilepsia. 1997; 38: 1270-1274
        • Hrachovy R.A
        • Frost Jr, J.D
        Infantile spasms.
        Pediatr Clin North Am. 1989; 36: 311-329
        • Snead III, O.C
        Treatment of infantile spasms.
        Pediatr Neurol. 1990; 6: 147-150
        • Commission on Classification and Terminology of the International League Against Epilepsy
        Revised classification of epilepsies, epileptic syndromes and related disorders.
        Epilepsia. 1989; 30: 389-399
        • Vigevano F
        • Fusco L
        • Cusmai R
        • Claps D
        • Ricci S
        • Milani L
        The idiopathic form of West syndrome.
        Epilepsia. 1993; 34: 743-746
        • Wang M.C
        • Mak S.C
        • Chi C.S
        • Chen C.H
        • Shian W.J
        A long-term follow-up study of West syndrome.
        Chin Med J. 1994; 53: 158-162
        • Watanabe K
        West syndrome: etiological and prognostic aspects.
        Brain Dev. 1998; 20: 1-8
      1. Ministry of the Interior, editor. Statistical yearbook of interior, 1999. Ministry of the Interior, Taipei, The Republic of China, 2000.

        • Cowan L.D
        • Hudson L.S
        The epidemiology and natural history of infantile spasms.
        J Child Neurol. 1991; 6: 355-364
        • Rantala H
        • Putkonen T
        Occurrence, outcome, and prognostic factors of infantile spasms and Lennox–Gastaut syndrome.
        Epilepsia. 1999; 40: 286-289
        • Lerman P
        • Kivity S
        The efficacy of corticotropin in primary infantile spasms.
        J Pediatr. 1982; 101: 294-296
        • Glaze D.G
        • Hrachovy R.A
        • Frost Jr, J.D
        • Kellaway P
        • Zion T.E
        Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisolone.
        J Pediatr. 1988; 112: 389-396
        • Hrachovy R.A
        • Glaze D.G
        • Frost Jr, J.D
        A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms.
        Epilepsia. 1991; 32: 212-214
        • Riikonen R
        Long-term outcome of West syndrome: a study of adults with a history of infantile spasms.
        Epilepsia. 1996; 37: 367-372
        • Appleton R.E
        Infantile spasms.
        Arch Dis Child. 1993; 69: 614-618
        • Matsumoto A
        • Watanabe K
        • Negoro T
        • Sugiura M
        • Iwase K
        • Hara K
        • et al.
        Long-term prognosis after infantile spasms. A statistical study of prognostic factors in 200 cases.
        Dev Med Child Neurol. 1981; 23: 51-65
        • Koo B
        • Hwang P.A
        • Logan W.J
        Infantile spasms: outcome and prognostic factors of cryptogenic and symptomatic groups.
        Neurology. 1993; 43: 2322-2327