Review article| Volume 23, ISSUE 7, P539-541, November 2001

Download started.


Epidemiological data of West syndrome in Finland


      The present study examined whether changes in the incidence of West syndrome (WS) could be used to evaluate changes in the quality of prenatal care over time. The incidence of WS in Finland did not change (1960–1991) in spite of increased survival of low-birth-weight infants. Small-for-gestational age (SGA) infants were more apt to develop infantile spasms than preterm average-for-gestational age infants. The number of SGA infants with neonatal hypoglycemia and infantile spasms decreased significantly. The number of cases of brain malformation and tuberous sclerosis increased; this probably reflects the development of more refined neuroradiological screening methods. Early prenatal factors seem to play a major role in the genesis of infantile spasms. Little can be done to reduce the incidence of WS, but every effort should be made to reduce the number of SGA infants by good prenatal care and treating neonatal hypoglycemia carefully.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Piekkala P
        • Erkkola R
        • Kero P
        • Tenovuo A
        • Sillanpää M
        Declining perinatal mortality in a region of Finland 1968-82.
        Am J Public Health. 1985; 75: 156-160
        • Riikonen R
        • Raumavirta S
        • Sinivuori E
        • Seppälä T
        Changing pattern of cerebral palsy in the south-west region of Finland.
        Acta Pediatr Scand. 1989; 78: 581-587
        • Riikonen R
        Decreasing perinatal mortality: unchanged infantile spasm morbidity.
        Dev Med Child Neurol. 1995; 37: 232-238
        • Hattori H
        • Wasterlain C
        Excitatory amino acids in the developing brain: ontogeny, plasticity, and excitotoxicity.
        Pediatr Neurol. 1990; 6: 219-228
        • Silverstein F
        • Simpson J
        • Gordon K
        Hypoglycaemia alters striatal amino acid efflux in perinatal rats: an in vivo microdialysis study.
        Ann Neurol. 1990; 28: 516-521.3