Case report| Volume 23, ISSUE 6, P424-426, October 2001

Plasmapheresis in fulminant acute disseminated encephalomyelitis


      We report an 11-year-old girl with acute disseminated encephalomyelitis (ADEM) who developed respiratory failure and coma despite the use of corticosteroid and intravenous immunoglobulin. We performed plasmapheresis four times, which improved her level of consciousness, hyperesthesia, external ophthalmoplegia and muscle weakness, and led to the normalization of brain and spinal cord MRI. Plasmapheresis might be an effective treatment in cases of fulminant ADEM.


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        • Johnson R.T.
        The pathogenesis of acute viral encephalitis and postinfectious encephalomyelitis.
        J Infect Dis. 1987; 15: 359-364
        • Fazakerley J.K.
        • Buchmeier M.J.
        Pathogenesis of virus-induced demyelination.
        Adv Virus Res. 1993; 42: 249-324
        • Straub J.
        • Chofflon M.
        • Delavelle J.
        Early high-dose intravenous methylpredisolone in acute disseminated encephalomyelitis; a successful recovery.
        Neurology. 1997; 49: 1145-1147
        • Mancini J.
        • Chabrol B.
        • Moulene E.
        • Pinsard N.
        Relapsing acute encephalopathy: a complication of diphtheria-tetanus-poliomyelitis immunization n a young boy.
        Eur J Pediatr. 1996; 155: 136-138
        • Dodick D.W.
        • Silber M.H.
        • Noseworthy J.H.
        • Wilbright W.A.
        • Rodriguez M.
        Acute disseminated encephalomyelitis after accidental injection of a hog vaccine: successful treatment with plasmapheresis.
        Mayo Clin Proc. 1998; 73: 1193-1195
        • Jubelt B.
        • Miller J.R.
        Viral infections.
        in: Rowland L.P. Merritt's textbook of neurology. 9th ed. Williams and Wilkins, Philadelphia1995
        • Stricker R.B.
        • Miller R.G.
        • Kiprov D.D.
        Role of plasmapheresis in acute disseminated (postinfectious) encephalomyelitis.
        J Clin Apheresis. 1992; 7: 173-179
        • Kanter D.S.
        • Horensky D.
        • Sperling R.A.
        • Kaplan J.D.
        • Malachowski M.E.
        • Churchill Jr, W.H.
        Plasmapheresis in fulminant acute disseminated encephalomyelitis.
        Neurology. 1995; 45: 824-827
        • Paolo B.
        • Salvatore G.
        • Antonio A.
        • Macro B.
        Plasmapheresis in a child affected by acute disseminated encephalomyelitis.
        Brain Dev. 2000; 22: 136-136
        • Apak R.A.
        • Anlar B.
        • Saatci I.
        A case of relapsing acute disseminated encephalomyelitis with high dose corticosteroid treatment.
        Brain Dev. 1999; 21: 279-282