In recent years, mesial temporal lobe epilepsy has been recognized as a distinct epileptic
syndrome associated with hippocampal or mesial temporal sclerosis. The pathological
process leading to this medically refractory epilepsy acts on the developing brain.
In the clinical history, an early, acute, usually convulsive and often febrile episode
is followed at a variable latency by recurring seizures, whose clinical symptomatology
is consistent with the involvement of limbic structures. Their symptomatology is highly
variable ranging from short periods of loss of contact to complex phenomenology including
autonomic and emotional manifestations, illusions, hallucinations and automatisms,
that can hardly be accounted for by a dysfunction of an individual structure. Although
the seizures are refractory to antiepileptics, anteromesial temporal lobectomy can
abolish disabling seizures in 80–90% of the patients, and early surgical intervention
will prevent psychosocial consequences.
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© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
