Early infantile epileptic encephalopathy (Ohtahara syndrome) after maternal electric injury during pregnancy: etiological considerations


      Early infantile epileptic encephalopathy (EIEE) is a polyetiologic age-dependent neurological disorder. We present two patients with EIEE whose mothers experienced electric injury during pregnancy. After the accident one mother noticed decreased fetal movements. Neither other prenatal factors nor intrapartal damage or postnatally examined structural, metabolic or infectious causes which might have been responsible for the EIEE in these children could be found. The question of electric accident during pregnancy should be considered when documenting the history of children with Ohtahara syndrome.


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        • Ohtahara S.
        • Ohtsuka Y.
        • Yamatogi Y.
        • Oka E.
        The early-infantile encephalopathy with suppression-burst: developmental aspects.
        Brain Dev. 1987; 9: 371-376
        • Clarke M.
        • Gill J.
        • Noronha M.
        • McKinlay I.
        Early infantile epileptic encephalopathy with suppression burst: Ohtahara syndrome.
        Dev Med Child Neurol. 1987; 29: 520-528
        • Verrotti A.
        • Domizio S.
        • Sabatino G.
        • Morgese G.
        Early infantile epileptic encephalopathy: a long-term follow-up study.
        Child's Nerv Syst. 1996; 12: 530-533
        • Aicardi J.
        • Goutières F.
        Encephalopathie myoclonique néonatale.
        Rev EEG Neurophysiol. 1978; 8: 99-101
        • Aicardi J.
        Early myoclonic encephalopathy (neonatal myoclonic encephalopathy).
        in: Roger J. Bureau M. Dravet C. Dreifuss F.E. Perret A. Wolf P. Epileptic syndromes in infancy, childhood and adolescence. 2nd ed. John Libbey and Company Ltd, London1992: 13-23
        • Pueschel S.M.
        • Louis S.
        • McKnight P.
        Seizure disorders in Down syndrome.
        Arch Neurol. 1991; 48: 318-320
        • Ohtahara S.
        • Ohtsuka Y.
        • Yamatogi Y.
        • Oka E.
        • Yoshinaga H.
        • Sato M.
        Prenatal etiologies of West syndrome.
        Epilepsia. 1993; 34: 716-722
        • Leiberman J.R.
        • Mazor M.
        • Molcho J.
        • Haiam E.
        • Maor E.
        • Insler V.
        Electrical accidents during pregnancy.
        Obstet Gynecol. 1986; 6: 861-863
        • Einarson A.
        • Bailey B.
        • Inocencion G.
        • Ormond K.
        • Koren G.
        Accidental electric shock in pregnancy: a prospective cohort study.
        Am J Obstet Gynecol. 1997; 176: 678-681
        • Jaffe R.
        • Fejgin M.
        • Aderet N.
        Fetal death in early pregnancy due to electric current.
        Acta Obstet Gynecol Scand. 1986; 65: 283
        • Yoong A.F.
        Electrical shock sustained in pregnancy followed by placental abruption.
        Postgrad Med J. 1990; 66: 563-564
        • Repke J.T.
        • Berger N.
        Electroconvulsive therapy in pregnancy.
        Obstet Gynecol. 1984; 63: 39S-41S
        • D'Souza S.W.
        • McConnell S.E.
        • Slater P.
        • Barson A.J.
        Glycine site of the excitatory amino acid N-methyl-d-aspartate receptor in neonatal and adult brain.
        Arch Dis Child. 1993; 69: 212-215
        • Hamosh A.
        • Johnston M.V.
        • Valle D.
        Nonketotic hyperglycinemia.
        in: Scriver C.R. Beaudet A.L. Sly W.S. Valle D. The metabolic and molecular basis of inherited disease. 7th ed. McGraw-Hill Inc, New York1995: 1337-1346
        • Schmitt B.
        • Steinmann B.
        • Gitzelmann R.
        • Thun-Hohenstein L.
        • Mascher H.
        • Dumermuth G.
        Nonketotic hyperglycinemia: clinical and electrophysiologic effects of dextromethorphan, an antagonist of the NMDA receptor.
        Neurology. 1993; 43: 421-424
        • Ohtahara S.
        • Ohtsuka Y.
        • Yamatogi Y.
        • Oka E.
        • Inoue H.
        Early-infantile epileptic encephalopathy with suppression-bursts.
        in: Roger J. Bureau M. Dravet C. Dreifuss R.E. Perret A. Wolf P. Epileptic syndromes in infancy, childhood and adolescence. 2nd ed. John Libbey and Company Ltd, London1992: 25-34