Advertisement
Original article| Volume 23, ISSUE 5, P317-320, August 2001

Download started.

Ok

Prevalence of positive anticardiolipin antibody in benign infantile convulsion

      Abstract

      We report six anticardiolipin antibody (aCL)-positive cases among 18 children with epilepsy showing various seizure types in our initial study. These six cases revealed normal coagulation tests. As three of these six cases involved benign infantile convulsion (BIC), we further investigated the high frequency of positive aCL-Immunoglobulin (Ig) G in BIC in our subsequent study of nine cases that included three cases from the previous study and an additional six BIC cases followed and/or diagnosed by co-author (T.K.). As a result, eight of nine BIC cases were positive for aCL-IgG and the values of aCL-IgG decreased over long-term observation in three of these cases. The frequency of positivity for aCL-IgG in BIC was obviously higher than that of controls. Based on these results, we suggest that some immunological responses may be responsible for the pathogenesis of BIC.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Hughes G.R.
        The anticardiolipin syndrome.
        Clin Exp Rheumatol. 1985; 3: 285-286
        • Shergy W.J.
        • Kredich D.W.
        • Pisetsky D.S.
        Patterns of autoantibody expression in pediatric and adult systemic lupus erythematosus.
        J Rheumatol. 1989; 16: 1329-1334
        • Pelkonen P.
        • Simell O.
        • Rasi V.
        • Vaarala O.
        Venous thrombosis associated with lupus anticoagulant and anticardiolipin antibodies.
        Acta Paediatr Scand. 1988; 77: 767-772
        • Ravelli A.
        • Caporali R.
        • Bianchi E.
        • Viola S.
        • Solmi M.
        • Montecucco C.
        • et al.
        Anticardiolipin syndrome in childhood: a report of two cases.
        Clin Exp Rheumatol. 1990; 8: 95-98
        • Angelini L.
        • Granata T.
        • Zibordi F.
        • Binelli S.
        • Zorzi G.
        • Besana C.
        Partial seizures associated with antiphospholipid antibodies in childhood.
        Neuropediatrics. 1998; 29: 249-253
        • Angelini L.
        • Zibordi F.
        • Zorzi G.
        • Nardocci N.
        • Caporali R.
        • Ravelli A.
        • et al.
        Neurological disorders, other than stroke, associated with antiphospholipid antibodies in childhood.
        Neuropediatrics. 1996; 27: 149-153
        • Commission on Classification and Terminology of the International League Against Epilepsy
        Proposal for revised classification of epilepsies and epileptic syndromes.
        Epilepsia. 1989; 30: 389-399
        • Watanabe K.
        • Negoro T.
        • Aso K.
        Benign partial epilepsy with secondarily generalized seizures in infancy.
        Epilepsia. 1993; 34: 635-638
        • Caporali R.
        • Ravelli A.
        • De Gennaro F.
        • Neirotti G.
        • Montecucco C.
        • Martini A.
        Prevalence of anticardiolipin antibodies in juvenile chronic arthritis.
        Ann Rheum Dis. 1991; 50: 599-601
        • Angelini L.
        • Ravelli A.
        • Caporali R.
        • Rumi V.
        • Nardocci N.
        • Martini A.
        High prevalence of antiphospholipid antibodies in children with idiopathic cerebral ischemia.
        Pediatrics. 1994; 94: 500-503
        • Muir K.W.
        • Squire I.B.
        • Alwan W.
        • Lees K.R.
        Anticardiolipin antibodies in an unselected stroke population.
        Lancet. 1994; 344: 452-456
        • Carreras L.O.
        • Defreyn G.
        • Machin S.J.
        • Vermylen J.
        • Deman R.
        • Spitz B.
        • et al.
        Arterial thrombosis, intrauterine death and ‘lupus’ anticoagulant: detection of immunoglobulin interfering with prostacyclin formation.
        Lancet. 1981; 1: 244-246
        • Coull B.M.
        • Goodnight S.H.
        Antiphospholipid antibodies, prethrombotic states, and stroke.
        Stroke. 1990; 21: 1370-1374
        • Schorer A.E.
        • Wickham N.W.
        • Watson K.V.
        Lupus anticoagulant induces a selective defect in thrombin-mediated endothelial prostacyclin release and platelet aggregation.
        Br J Haematol. 1989; 71: 399-407
        • Chapman J.
        • Cohen-Armon M.
        • Korczyn A.D.
        Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes.
        Lupus. 1999; 8: 127-133
        • Terwindt G.M.
        • Ophoff R.A.
        • Lindhout D.
        • Haan J.
        • Halley D.J.
        • Sandkuijl L.A.
        • et al.
        Partial cosegregation of familial hemiplegic migraine and a benign familial infantile epileptic syndrome.
        Epilepsia. 1997; 38: 915-921