Abstract
We report six anticardiolipin antibody (aCL)-positive cases among 18 children with
epilepsy showing various seizure types in our initial study. These six cases revealed
normal coagulation tests. As three of these six cases involved benign infantile convulsion
(BIC), we further investigated the high frequency of positive aCL-Immunoglobulin (Ig)
G in BIC in our subsequent study of nine cases that included three cases from the
previous study and an additional six BIC cases followed and/or diagnosed by co-author
(T.K.). As a result, eight of nine BIC cases were positive for aCL-IgG and the values
of aCL-IgG decreased over long-term observation in three of these cases. The frequency
of positivity for aCL-IgG in BIC was obviously higher than that of controls. Based
on these results, we suggest that some immunological responses may be responsible
for the pathogenesis of BIC.
Keywords
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Article info
Publication history
Accepted:
May 23,
2001
Received in revised form:
May 22,
2001
Received:
September 25,
2000
Identification
Copyright
© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
